Association of genetic risk, lifestyle, and their interaction with obesity and obesity-related morbidities

IF 27.7 1区生物学 Q1 CELL BIOLOGY

Cell metabolism Pub Date : 2024-07-02 DOI:10.1016/j.cmet.2024.06.004

Min Seo Kim, Injeong Shim, Akl C. Fahed, Ron Do, Woong-Yang Park, Pradeep Natarajan, Amit V. Khera, Hong-Hee Won

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Abstract

The extent to which modifiable lifestyle factors offset the determined genetic risk of obesity and obesity-related morbidities remains unknown. We explored how the interaction between genetic and lifestyle factors influences the risk of obesity and obesity-related morbidities. The polygenic score for body mass index was calculated to quantify inherited susceptibility to obesity in 338,645 UK Biobank European participants, and a composite lifestyle score was derived from five obesogenic factors (physical activity, diet, sedentary behavior, alcohol consumption, and sleep duration). We observed significant interaction between high genetic risk and poor lifestyles (p_interaction < 0.001). Absolute differences in obesity risk between those who adhere to healthy lifestyles and those who do not had gradually expanded with an increase in polygenic score. Despite a high genetic risk for obesity, individuals can prevent obesity-related morbidities by adhering to a healthy lifestyle and maintaining a normal body weight. Healthy lifestyles should be promoted irrespective of genetic background.

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遗传风险、生活方式及其与肥胖和肥胖相关疾病的相互作用的关系

可改变的生活方式因素能在多大程度上抵消肥胖和肥胖相关疾病的遗传风险，目前仍是未知数。我们探讨了遗传因素和生活方式因素之间的相互作用如何影响肥胖和肥胖相关疾病的风险。我们计算了 338,645 名英国生物库欧洲参与者的体重指数多基因评分，以量化肥胖的遗传易感性，并从五个致胖因素（体力活动、饮食、久坐行为、饮酒和睡眠时间）中得出了综合生活方式评分。我们观察到高遗传风险与不良生活方式之间存在明显的相互作用（pinteraction < 0.001）。随着多基因评分的增加，坚持健康生活方式者与不坚持健康生活方式者之间肥胖风险的绝对差异逐渐扩大。尽管肥胖的遗传风险很高，但个人可以通过坚持健康的生活方式和保持正常体重来预防与肥胖相关的疾病。无论遗传背景如何，都应提倡健康的生活方式。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell metabolism 生物-内分泌学与代谢

CiteScore

48.60

自引率

1.40%

发文量

173

审稿时长

2.5 months

期刊介绍： Cell Metabolism is a top research journal established in 2005 that focuses on publishing original and impactful papers in the field of metabolic research.It covers a wide range of topics including diabetes, obesity, cardiovascular biology, aging and stress responses, circadian biology, and many others. Cell Metabolism aims to contribute to the advancement of metabolic research by providing a platform for the publication and dissemination of high-quality research and thought-provoking articles.