Improving quality of life, sleep and mental health through multicomponent training versus Brazilian recommendations of physical activity in post-COVID-19 patients: CORE-study–A randomized controlled trial

IF 2.3 3区医学 Q2 PSYCHIATRY

Mental Health and Physical Activity Pub Date : 2024-06-25 DOI:10.1016/j.mhpa.2024.100615

Maria Eduarda de Moraes Sirydakis , Angelica Danielevicz , Paulo Urubatan Gama de Melo , Juliane Bregalda , Marina Isolde Constantini , Guilherme Pelliciari , Suelen Katiê Sampaio , Cassiano Ricardo Rech , Rosemeri Maurici , Aline Mendes Gerage , Rodrigo Sudatti Delevatti

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引用次数: 0

Abstract

Background and objectives

To analyze the effects of multicomponent training on the quality of life (Qol), sleep quality (SQ), depressive symptoms (DS), and health perception (HP) in adults and elderly individuals post-COVID-19 infection.

Methods

Randomized controlled clinical trial, with an intervention group (IG) of multicomponent physical training lasting 11 weeks and a control group (CG). The participants were adults and elderly people, of both genders, who were infected with COVID-19 in its moderate to severe type. The study was carried out in Florianópolis, Santa Catarina, Brazil from November 2021 to April 2023. The training program consisted of balance, strength and aerobic exercises. QoL, DS, SQ and HP were evaluated at baseline and at the 12th week. Outcomes were analyzed by Protocol (PP) and by Intention to Treat (ITT). Generalized Estimating Equations were used, with Bonferroni post-hoc; α: 0.05.

Results

Thirty-nine subjects (19 women, 52.50 ± 12.97 years old) composed the sample. In the ITT analysis, an improvement in QoL was observed only in the intervention group (IG-pre: 10.70 ± 0.77, post: 8.83 ± 0.82, p < 0.001; CG-pre: 10.11 ± 0.81, post:11.00 ± 1.11, p = 0.408). In relation to SQ, improvement was also found only in the IG (IG-pre: 8.80 ± 0.94, post: 6.47 ± 0,88, p < 0.001; CG-pre: 7.00 ± 1,04, post: 7.21 ± 1.20, p = 0.768). In DS, improvement was observed (p < 0.001) in both groups (IG-pre: 8.89 ± 1.14, post: 4.71 ± 1.22; CG-pre: 9.06 ± 1.68, post: 6.92 ± 1.80). In the PP analysis, only SQ and DS improved in both groups. No significant improvements were observed in any of the analyses for the HP outcome.

Conclusion

Multicomponent training demonstrated superiority in enhancing QoL and SQ, and both approaches (multicomponent training and recommendations for physical activity) appear to mitigate depressive symptoms. Both approaches seem not to significantly improve HP.

Brazilian clinical trials registry

RBR-10y6jhr.

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通过多组分训练与巴西建议的体育锻炼相比，改善 COVID-19 后患者的生活质量、睡眠和心理健康：CORE 研究--随机对照试验

背景和目的分析多成分训练对感染 COVID-19 后的成年人和老年人的生活质量（Qol）、睡眠质量（SQ）、抑郁症状（DS）和健康感知（HP）的影响。方法随机对照临床试验，干预组（IG）和对照组（CG）分别进行为期 11 周的多成分体能训练。参与者为感染 COVID-19 中重度病毒的成年人和老年人，男女均有。研究于 2021 年 11 月至 2023 年 4 月在巴西圣卡塔琳娜州弗洛里亚诺波利斯市进行。训练计划包括平衡、力量和有氧运动。在基线和第12周时对QoL、DS、SQ和HP进行评估。结果按方案（PP）和治疗意向（ITT）进行分析。采用广义估计方程，Bonferroni post-hoc; α：结果样本中有 39 名受试者（19 名女性，52.50 ± 12.97 岁）。在 ITT 分析中，只观察到干预组的 QoL 有所改善（IG-前：10.70 ± 0.77，后：8.83 ± 0.82，α：0.05）：8.83±0.82，p < 0.001；CG-前：10.11±0.81，后：11.00±1.11，p = 0.408）。在 SQ 方面，只有 IG 有改善（IG-前：8.80 ± 0.94，后：6.47 ± 0.88，p = 0.001）：6.47±0.88，p < 0.001；CG-前：7.00±1.04，后：7.21±1.20，p = 0.408：7.21 ± 1.20, p = 0.768).在 DS 方面，两组均观察到了改善（p < 0.001）（IG-前：8.89 ± 1.14，后：4.71 ± 1.22；CG-前：4.71 ± 1.22，后：4.71 ± 1.22）：4.71±1.22；CG-前：9.06±1.68，后：6.92±1.80）：6.92 ± 1.80).在 PP 分析中，两组中只有 SQ 和 DS 有改善。结论多组分训练在提高 QoL 和 SQ 方面具有优势，两种方法（多组分训练和体育活动建议）似乎都能减轻抑郁症状。巴西临床试验登记处RBR-10y6jhr。

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来源期刊

Mental Health and Physical Activity PSYCHIATRY-

CiteScore

6.70

自引率

6.40%

发文量

审稿时长

32 days

期刊介绍： The aims of Mental Health and Physical Activity will be: (1) to foster the inter-disciplinary development and understanding of the mental health and physical activity field; (2) to develop research designs and methods to advance our understanding; (3) to promote the publication of high quality research on the effects of physical activity (interventions and a single session) on a wide range of dimensions of mental health and psychological well-being (eg, depression, anxiety and stress responses, mood, cognitive functioning and neurological disorders, such as dementia, self-esteem and related constructs, psychological aspects of quality of life among people with physical and mental illness, sleep, addictive disorders, eating disorders), from both efficacy and effectiveness trials;