Manganese carbonate superparticles as DNA- and pH-responsive magnetic resonance imaging contrast agents

IF 8.2 2区 材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY
Leshan Chen , Peng Zhao , Linyan Song , Kui Luo , Nan Xie , Hao Wang , Ling Ye
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Abstract

Manganese carbonate nanoparticles (NPs) have been developed as pH-triggered responsive magnetic resonance imaging (MRI) contrast agents for tumor diagnosis, but the signal amplification of MRI is still limited due to the lack of response to other pathological parameters of tumors. Here, random single-stranded deoxyribonucleic acid (ssDNA) was explored as a biomimetic template to prepare manganese carbonate superparticles (MnCO3 SPs) assembled from ultrasmall particles. We focused on the degradation ability of DNA-MnCO3 SPs triggered by DNA and its trigger mechanism. The results show that different sequences of DNA could trigger the disassembly of these DNA-MnCO3 SPs and result in MR signal amplification. Further investigations show the DNA-MnCO3 SPs possess good physiological stability, but increased degradation sensitivity under dual triggering of DNA and low pH. In vivo MR and FL dual-modal imaging for tumor region display T1-signal rapid amplification, suggesting rapid responsiveness of DNA-MnCO3 SPs to DNA. Therefore, the design of DNA- and pH-triggered DNA-MnCO3 SPs may provide a new idea for the construction of next-generation activatable contrast agents with high specificity and high sensitivity.

Abstract Image

作为 DNA 和 pH 响应型磁共振成像对比剂的碳酸锰超微粒
碳酸锰纳米粒子(NPs)已被开发为用于肿瘤诊断的pH触发响应型磁共振成像(MRI)造影剂,但由于缺乏对肿瘤其他病理参数的响应,MRI的信号放大仍然有限。在此,我们探索了将随机单链脱氧核糖核酸(ssDNA)作为生物仿生模板来制备由超小颗粒组装而成的碳酸锰超颗粒(MnCO3 SPs)。我们重点研究了 DNA-MnCO3 SPs 在 DNA 触发下的降解能力及其触发机制。结果表明,不同序列的DNA可触发这些DNA-MnCO3 SPs的解体,并导致磁共振信号放大。进一步的研究表明,DNA-MnCO3 SPs 具有良好的生理稳定性,但在 DNA 和低 pH 值的双重触发下,降解敏感性增加。肿瘤区域的体内 MR 和 FL 双模态成像显示 T1 信号快速放大,表明 DNA-MnCO3 SPs 对 DNA 具有快速响应性。因此,设计DNA和pH触发的DNA-MnCO3 SPs可为构建高特异性和高灵敏度的下一代可激活造影剂提供新思路。
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来源期刊
CiteScore
11.30
自引率
3.90%
发文量
130
审稿时长
31 days
期刊介绍: Materials Today Nano is a multidisciplinary journal dedicated to nanoscience and nanotechnology. The journal aims to showcase the latest advances in nanoscience and provide a platform for discussing new concepts and applications. With rigorous peer review, rapid decisions, and high visibility, Materials Today Nano offers authors the opportunity to publish comprehensive articles, short communications, and reviews on a wide range of topics in nanoscience. The editors welcome comprehensive articles, short communications and reviews on topics including but not limited to: Nanoscale synthesis and assembly Nanoscale characterization Nanoscale fabrication Nanoelectronics and molecular electronics Nanomedicine Nanomechanics Nanosensors Nanophotonics Nanocomposites
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