Dual-responsive, highly bacteriostatic and swellable chitosan-based hydrogels loaded with 5-fluorouracil for sustainable release

IF 4.5 3区工程技术 Q1 CHEMISTRY, APPLIED

Reactive & Functional Polymers Pub Date : 2024-06-20 DOI:10.1016/j.reactfunctpolym.2024.105992

Yaxue Xie , Pingxiong Cai , Huining Xiao , Yuanfeng Pan

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Abstract

In this work, a dual-responsive hydrogel for sustainable release of drug was prepared using chitosan grafted with PBA as substrate to form semi-interpenetrating polymer networks (S-IPN) via free-radical crosslinking polymerization of acrylic acid in the presence of MBAA as a crosslinker and KPS as an initiator as well as Fe³⁺.ions introduced. The results from comprehensive characterization indicated that the as-prepared hydrogel possesses cavity structure with the pores of varying sizes, thus facilitating the accommodation of 5-fluorouracil as a model drug. In addition, the swelling behavior of the hydrogels in different pH buffers and glucose solutions was also investigated. As expected, the prepared hydrogels are pH and glucose responsive due to PAA and phenylboronic acid incorporated into the hydrogel, which enables the slow or sustainable release of drug. Moreover, the release processes were fitted with various kinetic models whereas the release was better described by Korsmeyer-Peppas model or the drug release is mainly governed by the release mechanism of the hydrogel is primarily driven by Fickian diffusion from a mechanical point of view. Hydrogel loaded with drug was found to have good antibacterial effects against E. coli and S. aureus, leading to the potential for various medical-related applications.

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载入 5-氟尿嘧啶的双响应、高抑菌性和可溶胀壳聚糖基水凝胶可实现持续释放

本研究以壳聚糖接枝 PBA 为基质，在以 MBAA 为交联剂、KPS 为引发剂并引入 Fe3+ 离子的条件下，通过丙烯酸自由基交联聚合形成半互穿聚合物网络（S-IPN），制备了一种可持续释放药物的双响应水凝胶。综合表征结果表明，所制备的水凝胶具有空腔结构，孔隙大小不一，因此有利于容纳 5-氟尿嘧啶这种模型药物。此外，还研究了水凝胶在不同 pH 缓冲溶液和葡萄糖溶液中的溶胀行为。不出所料，由于水凝胶中加入了 PAA 和苯硼酸，制备的水凝胶对 pH 和葡萄糖具有响应性，从而实现了药物的缓慢或持续释放。此外，用各种动力学模型对释放过程进行了拟合，其中 Korsmeyer-Peppas 模型对释放过程的描述较好，或者从机械角度来看，水凝胶的释放机制主要由菲氏扩散驱动。研究发现，含有药物的水凝胶对大肠杆菌和金黄色葡萄球菌具有良好的抗菌效果，因此具有各种医疗相关应用的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Reactive & Functional Polymers 工程技术-高分子科学

CiteScore

8.90

自引率

5.90%

发文量

259

审稿时长

27 days

期刊介绍： Reactive & Functional Polymers provides a forum to disseminate original ideas, concepts and developments in the science and technology of polymers with functional groups, which impart specific chemical reactivity or physical, chemical, structural, biological, and pharmacological functionality. The scope covers organic polymers, acting for instance as reagents, catalysts, templates, ion-exchangers, selective sorbents, chelating or antimicrobial agents, drug carriers, sensors, membranes, and hydrogels. This also includes reactive cross-linkable prepolymers and high-performance thermosetting polymers, natural or degradable polymers, conducting polymers, and porous polymers. Original research articles must contain thorough molecular and material characterization data on synthesis of the above polymers in combination with their applications. Applications include but are not limited to catalysis, water or effluent treatment, separations and recovery, electronics and information storage, energy conversion, encapsulation, or adhesion.