The prevalence of human papillomavirus genotypes among patients with sexually transmitted HPV in north Iran

IF 2.3 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Clinical Epidemiology and Global Health Pub Date : 2024-07-01 DOI:10.1016/j.cegh.2024.101693

Sajad Salehi , Rana Rafiei , Reyhaneh Ghadarjani , Kaveh Gharaei Nejad

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Abstract

Objective

Given the high prevalence of sexually transmitted human papillomavirus (HPV) and the increasing number of individuals affected by this disease, the present study investigated the frequency of HPV genotypes in patients with sexually transmitted HPV.

Methods

In this cross-sectional study, samples of 2534 patients who were diagnosed with sexually transmitted HPV from 2016 to 2023, were examined for HPV genotype in Rasht, Iran. HPV infection was confirmed by performing a polymerase chain reaction (PCR), and samples were genotyped for classification. Also, data on the age and gender of patients were recorded, and all data was analyzed using SPSS version 22 with a significant level <0.05.

Results

The mean age of the patients was 33.8 ± 13.34 years, and 89.1 % were females. A total number of 4739 samples from 2534 patients were genotyped. About 52.2 % of HPV genotypes were low-risk HPV, and 47.8 % were high-risk HPV. HPV6 exhibited the highest prevalence in the low-risk category, while HPV16 showed the highest prevalence in the high-risk category. The frequency of HPV was significantly different among patients according to age and gender (P < 0.05).

Conclusion

Due to the high prevalence of sexually transmitted high-risk HPV, vaccination programs may lead to a reduction in sexually transmitted infections and alleviate the associated economic and social burdens.

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伊朗北部性传播人类乳头瘤病毒患者中人类乳头瘤病毒基因型的流行情况

目的鉴于性传播人乳头瘤病毒（HPV）的高发病率以及受这种疾病影响的人数不断增加，本研究调查了性传播 HPV 患者中 HPV 基因型的频率。方法在这项横断面研究中，对伊朗拉什特市 2016 年至 2023 年期间确诊为性传播 HPV 患者的 2534 例样本进行了 HPV 基因型检测。通过聚合酶链反应（PCR）确认 HPV 感染，并对样本进行基因分型分类。结果患者的平均年龄为 33.8±13.34 岁，89.1% 为女性。共对 2534 名患者的 4739 份样本进行了基因分型。约 52.2% 的 HPV 基因型为低风险 HPV，47.8% 为高风险 HPV。在低风险类别中，HPV6 的感染率最高，而在高风险类别中，HPV16 的感染率最高。结论由于性传播高危型 HPV 的高流行率，疫苗接种计划可能会导致性传播感染的减少，并减轻相关的经济和社会负担。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Epidemiology and Global Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-

CiteScore

4.60

自引率

7.70%

发文量

218

审稿时长

66 days

期刊介绍： Clinical Epidemiology and Global Health (CEGH) is a multidisciplinary journal and it is published four times (March, June, September, December) a year. The mandate of CEGH is to promote articles on clinical epidemiology with focus on developing countries in the context of global health. We also accept articles from other countries. It publishes original research work across all disciplines of medicine and allied sciences, related to clinical epidemiology and global health. The journal publishes Original articles, Review articles, Evidence Summaries, Letters to the Editor. All articles published in CEGH are peer-reviewed and published online for immediate access and citation.

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