Regulating Tissue Growth Factors for Healing With Etherified Carboxymethylcellulose Matrix.

IF 1.5 4区医学 Q3 CRITICAL CARE MEDICINE

Journal of Burn Care & Research Pub Date : 2024-11-14 DOI:10.1093/jbcr/irae124

Guiting Lin, Shandilya Ramdas, Hosam Hadid, Jared Van Vleet, Tom F Lue, Stathis Poulakidas

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引用次数: 0

Abstract

Etherified Carboxymethylcellulose Matrix (eCMC) is a revolutionary application of carboxymethylcellulose (CMC) in wound care, known for its potential in hemostasis and tissue regeneration. This study aims to investigate the mechanism of eCMC in tissue healing by establishing a rat burn model and administering eCMC as a treatment. The objective is to analyze cytokines and inflammatory mediators using a Cytokine Array and histochemical staining to understand the effects of eCMC on tissue regeneration. A rat burn model was created, and eCMC was applied as a treatment. Tissue samples were collected at multiple time points to assess the expression of cytokines and inflammatory mediators using a Cytokine Array. In addition, histochemical staining was performed to evaluate tissue regeneration factors. eCMC induced the expression of endogenous cytokines, particularly vascular epithelial growth factor and platelet-derived growth factor, while inhibiting inflammatory cytokines such as CINC-1, CINC-2, and MMP-8. This dual action facilitated wound healing and mitigated the risk of infection. eCMC demonstrates promising potential for enhancing skin regeneration. Further research is warranted to delve into the precise mechanism of eCMC's cytokine regulation. In vitro and in vivo studies should be conducted to comprehensively investigate the therapeutic capabilities of eCMC in wound healing.

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利用醚化羧甲基纤维素基质调节组织生长因子促进愈合

醚化羧甲基纤维素基质（eCMC）是羧甲基纤维素（CMC）在伤口护理方面的革命性应用，因其在止血和组织再生方面的潜力而闻名。本研究旨在通过建立大鼠烧伤模型并使用 eCMC 作为治疗方法，研究 eCMC 在组织愈合中的作用机制。目的是利用细胞因子阵列和组织化学染色分析细胞因子和炎症介质，以了解 eCMC 对组织再生的影响。我们创建了一个大鼠烧伤模型，并使用 eCMC 进行治疗。在多个时间点采集组织样本，使用细胞因子阵列评估细胞因子和炎症介质的表达。eCMC 可诱导内源性细胞因子的表达，尤其是血管内皮生长因子（VEGF）和表皮生长因子（PDGF），同时抑制炎性细胞因子，如 CINC-1、CINC-2 和 MMP-8。这种双重作用促进了伤口愈合并降低了感染风险。eCMC 在促进皮肤再生方面展现出了巨大的潜力。要深入研究 eCMC 调节细胞因子的确切机制，还需要进一步的研究。应开展体外和体内研究，以全面了解 eCMC 在伤口愈合方面的治疗能力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Burn Care & Research 医学-外科

CiteScore

2.60

自引率

21.40%

发文量

535

审稿时长

4-8 weeks

期刊介绍： Journal of Burn Care & Research provides the latest information on advances in burn prevention, research, education, delivery of acute care, and research to all members of the burn care team. As the official publication of the American Burn Association, this is the only U.S. journal devoted exclusively to the treatment and research of patients with burns. Original, peer-reviewed articles present the latest information on surgical procedures, acute care, reconstruction, burn prevention, and research and education. Other topics include physical therapy/occupational therapy, nutrition, current events in the evolving healthcare debate, and reports on the newest computer software for diagnostics and treatment. The Journal serves all burn care specialists, from physicians, nurses, and physical and occupational therapists to psychologists, counselors, and researchers.