The role and application of small extracellular vesicles in glioma.

IF 5.3 2区医学 Q1 ONCOLOGY

Cancer Cell International Pub Date : 2024-06-29 DOI:10.1186/s12935-024-03389-z

Zhihao Yang, HaoYuan Wu, ZhiWei Wang, ErBao Bian, Bing Zhao

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Abstract

Small extracellular vesicles (sEVs) are cell-derived, nanometer-sized particles enclosed by a lipid bilayer. All kinds of biological molecules, including proteins, DNA fragments, RNA, lipids, and metabolites, can be selectively loaded into sEVs and transmitted to recipient cells that are near and distant. Growing shreds of evidence show the significant biological function and the clinical significance of sEVs in cancers. Numerous recent studies have validated that sEVs play an important role in tumor progression and can be utilized to diagnose, stage, grading, and monitor early tumors. In addition, sEVs have also served as drug delivery nanocarriers and cancer vaccines. Although it is still infancy, the field of basic and translational research based on sEVs has grown rapidly. In this review, we summarize the latest research on sEVs in gliomas, including their role in the malignant biological function of gliomas, and the potential of sEVs in non-invasive diagnostic and therapeutic approaches, i.e., as nanocarriers for drug or gene delivery and cancer vaccines.

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细胞外小泡在胶质瘤中的作用和应用。

细胞外小泡（sEVs）是一种源自细胞、由脂质双分子层包裹的纳米级颗粒。各种生物分子，包括蛋白质、DNA 片段、RNA、脂质和代谢物，都可以选择性地装载到 sEVs 中，并传输到远近的受体细胞。越来越多的证据表明，sEVs 在癌症中具有重要的生物学功能和临床意义。最近的大量研究证实，sEVs 在肿瘤进展过程中发挥着重要作用，可用于诊断、分期、分级和监测早期肿瘤。此外，sEVs 还可用作给药纳米载体和癌症疫苗。基于 sEVs 的基础研究和转化研究虽然仍处于起步阶段，但发展迅速。在这篇综述中，我们总结了有关神经胶质瘤中 sEVs 的最新研究，包括它们在神经胶质瘤恶性生物功能中的作用，以及 sEVs 在非侵入性诊断和治疗方法中的潜力，即作为药物或基因递送的纳米载体和癌症疫苗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Cell International ONCOLOGY-

CiteScore

10.90

自引率

1.70%

发文量

360

审稿时长

1 months

期刊介绍： Cancer Cell International publishes articles on all aspects of cancer cell biology, originating largely from, but not limited to, work using cell culture techniques. The journal focuses on novel cancer studies reporting data from biological experiments performed on cells grown in vitro, in two- or three-dimensional systems, and/or in vivo (animal experiments). These types of experiments have provided crucial data in many fields, from cell proliferation and transformation, to epithelial-mesenchymal interaction, to apoptosis, and host immune response to tumors. Cancer Cell International also considers articles that focus on novel technologies or novel pathways in molecular analysis and on epidemiological studies that may affect patient care, as well as articles reporting translational cancer research studies where in vitro discoveries are bridged to the clinic. As such, the journal is interested in laboratory and animal studies reporting on novel biomarkers of tumor progression and response to therapy and on their applicability to human cancers.

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