Sample preparation and detection methods in point-of-care devices towards future at-home testing

IF 6.1 2区工程技术 Q1 BIOCHEMICAL RESEARCH METHODS

Lab on a Chip Pub Date : 2024-07-02 DOI:10.1039/D3LC00943B

George Adedokun, Morteza Alipanah and Z. Hugh Fan

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Abstract

Timely and accurate diagnosis is critical for effective healthcare, yet nearly half the global population lacks access to basic diagnostics. Point-of-care (POC) testing offers partial solutions by enabling low-cost, rapid diagnosis at the patient's location. At-home POC devices have the potential to advance preventive care and early disease detection. Nevertheless, effective sample preparation and detection methods are essential for accurate results. This review surveys recent advances in sample preparation and detection methods at POC. The goal is to provide an in-depth understanding of how these technologies can enhance at-home POC devices. Lateral flow assays, nucleic acid tests, and virus detection methods are at the forefront of POC diagnostic technology, offering rapid and sensitive tools for identifying and measuring pathogens, biomarkers, and viral infections. By illuminating cutting-edge research on assay development for POC diagnostics, this review aims to accelerate progress towards widely available, user-friendly, at-home health monitoring tools that empower individuals in personalized healthcare in the future.

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查看原文本刊更多论文

面向未来家庭检测的护理点设备中的样品制备和检测方法。

及时、准确的诊断对有效的医疗保健至关重要，然而全球近一半人口无法获得基本的诊断服务。护理点（POC）检测提供了部分解决方案，可在患者所在地进行低成本的快速诊断。家用 POC 设备具有推进预防保健和早期疾病检测的潜力。然而，有效的样本制备和检测方法对获得准确的结果至关重要。本综述探讨了 POC 样品制备和检测方法的最新进展。目的是深入了解这些技术如何增强家用 POC 设备。侧流检测、核酸测试和病毒检测方法是 POC 诊断技术的前沿，为识别和测量病原体、生物标记物和病毒感染提供了快速、灵敏的工具。本综述介绍了 POC 诊断化验开发方面的前沿研究，旨在加快普及用户友好型居家健康监测工具的进程，使个人在未来能够获得个性化的医疗保健服务。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Lab on a Chip 工程技术-化学综合

CiteScore

11.10

自引率

8.20%

发文量

434

审稿时长

2.6 months

期刊介绍： Lab on a Chip is the premiere journal that publishes cutting-edge research in the field of miniaturization. By their very nature, microfluidic/nanofluidic/miniaturized systems are at the intersection of disciplines, spanning fundamental research to high-end application, which is reflected by the broad readership of the journal. Lab on a Chip publishes two types of papers on original research: full-length research papers and communications. Papers should demonstrate innovations, which can come from technical advancements or applications addressing pressing needs in globally important areas. The journal also publishes Comments, Reviews, and Perspectives.