Ziwei Shi, Yujie Li, Xiuji Du, Dongsheng Liu and Yuanchen Dong*,
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引用次数: 0
Abstract
DNA hydrogel represents a potent material for crafting biological scaffolds, but the toolbox to systematically regulate the mechanical property is still limited. Herein, we have provided a strategy to tune the stiffness of DNA hydrogel through manipulating the rigidity of DNA modules. By introducing building blocks with higher molecular rigidity and proper connecting fashion, DNA hydrogel stiffness could be systematically elevated. These hydrogels showed excellent dynamic properties and biocompatibility, thus exhibiting great potential in three-dimensional (3D) cell culture. This study has offered a systematic method to explore the structure–property relationship, which may contribute to the development of more intelligent and personalized biomedical platforms.
DNA 水凝胶是制作生物支架的有效材料，但系统调节其机械性能的工具箱仍然有限。在这里，我们提供了一种通过操纵 DNA 模块的刚度来调节 DNA 水凝胶刚度的策略。通过引入分子刚度更高的构建模块和适当的连接方式，DNA 水凝胶的刚度可以得到系统性的提升。这些水凝胶显示出优异的动态特性和生物相容性，因此在三维（3D）细胞培养中具有巨大潜力。这项研究提供了一种探索结构-性能关系的系统方法，有助于开发更加智能化和个性化的生物医学平台。
期刊介绍：
Nano Letters serves as a dynamic platform for promptly disseminating original results in fundamental, applied, and emerging research across all facets of nanoscience and nanotechnology. A pivotal criterion for inclusion within Nano Letters is the convergence of at least two different areas or disciplines, ensuring a rich interdisciplinary scope. The journal is dedicated to fostering exploration in diverse areas, including:
- Experimental and theoretical findings on physical, chemical, and biological phenomena at the nanoscale
- Synthesis, characterization, and processing of organic, inorganic, polymer, and hybrid nanomaterials through physical, chemical, and biological methodologies
- Modeling and simulation of synthetic, assembly, and interaction processes
- Realization of integrated nanostructures and nano-engineered devices exhibiting advanced performance
- Applications of nanoscale materials in living and environmental systems
Nano Letters is committed to advancing and showcasing groundbreaking research that intersects various domains, fostering innovation and collaboration in the ever-evolving field of nanoscience and nanotechnology.
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