Assessment of essential and toxic trace element levels in erythrocytes of hemodialysis patients with end-stage renal disease

IF 3.6 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Trace Elements in Medicine and Biology Pub Date : 2024-06-21 DOI:10.1016/j.jtemb.2024.127491

Monika Rajkowska-Myśliwiec , Małgorzata Szczuko , Agata Witczak , Małgorzata Kaczkan , Sylwia Małgorzewicz

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引用次数: 0

Abstract

Background

Chronic kidney disease (CKD) is a global public health problem, resulting in end-stage kidney disease, cardiovascular disease, and premature death.

Aim

The aim of the study was to determine the profile of essential and toxic trace elements in erythrocytes of patients with end-stage renal disease (ESRD) and their relationship with selected anthropometric and biochemical parameters.

Methods

The present study compared the profiles of trace elements, including toxic sub-stances, in the erythrocytes of 80 hemodialysis patients with CKD with 40 healthy subjects. All patients had stage 5 CKD. The levels of Cd and Pb were determined by graphite furnace atomic absorption spectrometry and levels of Fe, Mn, Zn, Cu Cr, Ni, and Li by inductively coupled plasma atomic emission spectrometry.

Results

The ESRD patients demonstrated significantly lower Fe and Zn concentrations and significantly higher Mn and Li and toxic Pb and Cd concentrations in erythrocytes compared to those of the healthy controls. Negative correlations were observed, among others, between the concentrations of Cu, Li, and creatinine; Cu and phosphates; Mn, Pb, and transferrin saturation while positive correlations were noted between Cu, Cr, and transferrin and Pb, Cr, and the normalized protein catabolism rate.

Conclusions

The higher concentrations of toxic elements present in the erythrocytes of CKD patients might have resulted from the reduced ability of the kidneys to excrete them. Moreover, differences in the concentrations of essential elements (Fe, Mn, Zn) between the two groups indicated that their resorption in the kidneys of CKD patients was impaired. Patients with CKD might benefit from interventions intended to reduce high, toxic concentrations of Pb and Cd and Li and Mn as an alternative supportive treatment. Iron and zinc supplementation should be a component for the treatment of anemia in CKD patients.

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评估终末期肾病血液透析患者红细胞中必需和有毒微量元素的含量。

背景：慢性肾脏病（CKD）是一个全球性的公共卫生问题：目的：本研究旨在确定终末期肾病（ESRD）患者红细胞中必需微量元素和毒性微量元素的分布及其与某些人体测量和生化参数的关系：本研究比较了 80 名血液透析患者和 40 名健康人红细胞中微量元素（包括毒性亚稳态）的含量。所有患者均为慢性肾功能衰竭 5 期。石墨炉原子吸收光谱法测定了镉和铅的含量，电感耦合等离子体原子发射光谱法测定了铁、锰、锌、铜、铬、镍和锂的含量：结果：与健康对照组相比，ESRD 患者红细胞中铁和锌的浓度明显降低，锰和锂以及有毒铅和镉的浓度明显升高。除其他外，还观察到铜、锂和肌酐、铜和磷酸盐、锰、铅和转铁蛋白饱和度之间存在负相关，而铜、铬和转铁蛋白以及铅、铬和正常化蛋白质分解率之间存在正相关：慢性肾脏病患者红细胞中有毒元素的浓度较高，可能是由于肾脏排泄这些元素的能力下降所致。此外，两组患者体内必需元素（铁、锰、锌）浓度的差异表明，慢性肾脏病患者肾脏对这些元素的吸收能力减弱。作为一种替代性支持治疗方法，旨在降低铅、镉、锂和锰的高毒性浓度的干预措施可能会使慢性肾脏病患者受益。铁和锌的补充应该是治疗慢性肾脏病患者贫血的一个组成部分。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Trace Elements in Medicine and Biology 医学-内分泌学与代谢

CiteScore

6.60

自引率

2.90%

发文量

202

审稿时长

85 days

期刊介绍： The journal provides the reader with a thorough description of theoretical and applied aspects of trace elements in medicine and biology and is devoted to the advancement of scientific knowledge about trace elements and trace element species. Trace elements play essential roles in the maintenance of physiological processes. During the last decades there has been a great deal of scientific investigation about the function and binding of trace elements. The Journal of Trace Elements in Medicine and Biology focuses on the description and dissemination of scientific results concerning the role of trace elements with respect to their mode of action in health and disease and nutritional importance. Progress in the knowledge of the biological role of trace elements depends, however, on advances in trace elements chemistry. Thus the Journal of Trace Elements in Medicine and Biology will include only those papers that base their results on proven analytical methods. Also, we only publish those articles in which the quality assurance regarding the execution of experiments and achievement of results is guaranteed.