Comprehensive Review on Alzheimer's Disease: Natural Therapeutics, Gaps and Challenges.

Prem Shankar Mishra, Rakhi Mishra, Anuj Kumar
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Abstract

More than 20 million people worldwide have Alzheimer's disease (AD), making it the most prevalent disease. Patients with AD may live for at least a decade after diagnosis, making it the most common cause of disability in the elderly. Each year, 1% to 4% of the population is affected by AD, with prevalence peaking between ages 65 and 70 and declining to 6% among those over 85. Researchers have accumulated evidence on medicinal herbs that may reverse the pathogenesis of Alzheimer's disease. Alzheimer's disease (AD) is associated with severe memory loss, which can negatively impact social and professional life. The first neurotransmitter linked to Alzheimer's was acetylcholine (ACh). There is no known cure, and the available treatments are ineffective. Multiple studies indicate that Ayurvedic restorative herbs and their constituents may be effective in treating Alzheimer's disease. This technique emphasizes the fact that delaying or preventing Alzheimer's disease with the help of natural bio-actives could reduce the number of cases over the next half-century. To provide detailed information, the pathology and pathophysiology of Alzheimer's Disease are discussed in the text of this review, along with an overview of the neurotransmitters involved in the progression of the disease. The importance of different natural bioactives for the treatment of Alzheimer's disease is also outlined in the paper. The information contained in this paper can serve as a template for future research expressing the more beneficial role of other bioactive in acting as an adjuvant in the prevention and treatment of this disease, facing certain challenges and gaps with conventional drugs used to treat Alzheimer's disease.

阿尔茨海默病综合综述:自然疗法、差距与挑战。
全世界有 2000 多万人患有阿尔茨海默病(AD),是发病率最高的疾病。阿兹海默症患者在确诊后至少可以存活十年,是导致老年人残疾的最常见原因。每年有 1%至 4% 的人口受到注意力缺失症的影响,发病率在 65 岁至 70 岁之间达到高峰,在 85 岁以上的人群中则降至 6%。研究人员已经积累了可以逆转阿尔茨海默病发病机制的药草证据。阿尔茨海默病(AD)与严重的记忆力衰退有关,会对社交和职业生活产生负面影响。与阿尔茨海默病有关的第一种神经递质是乙酰胆碱(ACh)。目前还没有已知的治疗方法,现有的治疗效果也不佳。多项研究表明,阿育吠陀恢复性草药及其成分可有效治疗老年痴呆症。这项技术强调,在天然生物活性物质的帮助下延缓或预防阿尔茨海默病,可以在未来半个世纪内减少病例数量。为了提供详细信息,本综述将讨论阿尔茨海默病的病理学和病理生理学,并概述参与疾病进展的神经递质。文中还概述了不同天然生物活性物质对治疗阿尔茨海默病的重要性。本文所包含的信息可以作为未来研究的模板,表达其他生物活性物质在预防和治疗阿尔茨海默病中作为辅助剂所发挥的更有益的作用,因为传统治疗阿尔茨海默病的药物面临着某些挑战和差距。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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