Prognostic Outcome of Pulmonary Resection for Pulmonary Metastases from Gastric Cancer.

Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia Pub Date : 2024-01-01 DOI:10.5761/atcs.oa.24-00044

Go Kamimura, Masaya Aoki, Tadashi Umehara, Aya Harada-Takeda, Toshiyuki Nagata, Chihaya Koriyama, Kazuhiro Ueda

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Abstract

Purpose: Regardless of the devastating outcomes of pulmonary resection for metastases from gastric cancer, a handful of patients survive long after pulmonary metastasectomy. This study aimed to identify a good candidate for pulmonary resection for metastases from gastric cancer.

Methods: Between 2005 and 2023, 564 patients underwent pulmonary metastasectomy in our department, of which 12 patients underwent pulmonary resection for metastases from gastric cancer. Variables evaluated were the number and size of metastatic lesions, surgical procedure, disease-free interval (DFI), and the serum carcinoembryonic antigen at pulmonary metastasectomy.

Results: The DFI following gastrectomy ≤12.5 months group had a significantly worse overall survival (OS) than the other group (p = 0.005). A comparison between DFI following gastrectomy ≤12.5 months group and DFI following gastrectomy >12.5 months group showed a significant difference in serum carcinoembryonic antigen (CEA) value at pulmonary metastasectomy (p = 0.048). The serum CEA value at pulmonary metastasectomy >5.8 ng/ml group had a significantly worse OS than the other group (p = 0.001).

Conclusion: Pulmonary metastasectomy can be indicated in some patients with metastasis from gastric cancer who have longer DFI from gastrectomy and lower serum CEA at pulmonary metastasectomy.

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胃癌肺转移肺切除术的预后结果

目的：尽管胃癌转移肺切除术的结果令人沮丧，但仍有少数患者在肺转移切除术后长期存活。本研究旨在确定胃癌转移肺切除术的最佳候选者：2005年至2023年期间，我科共有564名患者接受了肺转移切除术，其中12名患者因胃癌转移而接受了肺切除术。评估变量包括转移病灶的数量和大小、手术方法、无病间隔期（DFI）以及肺转移切除术时的血清癌胚抗原：结果：胃切除术后 DFI≤12.5 个月组的总生存期（OS）明显低于其他组（P = 0.005）。胃切除术后 DFI ≤12.5 个月组与胃切除术后 DFI >12.5 个月组的比较显示，肺转移切除术时血清癌胚抗原（CEA）值存在显著差异（P = 0.048）。结论：肺转移灶切除术时血清癌胚抗原（CEA）值>5.8 ng/ml组的OS明显差于其他组（p = 0.001）：结论：肺转移灶切除术适用于胃切除术后DFI较长、肺转移灶切除术时血清CEA较低的部分胃癌转移患者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia

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