Cognitive and brain morphological deviations in middle-to-old aged autistic adults: A systematic review and meta-analysis

IF 7.5 1区医学 Q1 BEHAVIORAL SCIENCES

Neuroscience and Biobehavioral Reviews Pub Date : 2024-06-27 DOI:10.1016/j.neubiorev.2024.105782

Jingying Wang , Danielle Christensen , Stephen A. Coombes , Zheng Wang

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引用次数: 0

Abstract

Cognitive challenges and brain structure variations are common in autism spectrum disorder (ASD) but are rarely explored in middle-to-old aged autistic adults. Cognitive deficits that overlap between young autistic individuals and elderlies with dementia raise an important question: does compromised cognitive ability and brain structure during early development drive autistic adults to be more vulnerable to pathological aging conditions, or does it protect them from further decline? To answer this question, we have synthesized current theoretical models of aging in ASD and conducted a systematic literature review (Jan 1, 1980 - Feb 29, 2024) and meta-analysis to summarize empirical studies on cognitive and brain deviations in middle-to-old aged autistic adults. We explored findings that support different aging theories in ASD and addressed study limitations and future directions. This review sheds light on the poorly understood consequences of aging question raised by the autism community to pave the way for future studies to identify sensitive and reliable measures that best predict the onset, progression, and prognosis of pathological aging in ASD.

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中老年自闭症成人的认知和大脑形态偏差：系统回顾与荟萃分析。

自闭症谱系障碍（ASD）中常见的认知挑战和大脑结构变异，却很少在中老年自闭症成人中进行探讨。年轻自闭症患者与老年痴呆症患者之间重叠的认知缺陷提出了一个重要问题：早期发育过程中受损的认知能力和大脑结构是否会使成年自闭症患者更容易受到病理衰老状况的影响，还是会保护他们免于进一步衰退？为了回答这个问题，我们综合了目前关于自闭症成人衰老的理论模型，并进行了系统的文献综述（1980 年 1 月 1 日 - 2024 年 2 月 29 日）和荟萃分析，总结了关于中老年自闭症成人认知和大脑偏差的实证研究。我们探讨了支持自闭症不同衰老理论的研究结果，并讨论了研究的局限性和未来发展方向。这篇综述揭示了自闭症群体提出的衰老后果这一鲜为人知的问题，为今后的研究铺平了道路，以确定最能预测 ASD 病理衰老的发生、进展和预后的敏感可靠的测量方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuroscience and Biobehavioral Reviews 医学-行为科学

CiteScore

14.20

自引率

3.70%

发文量

466

审稿时长

6 months

期刊介绍： The official journal of the International Behavioral Neuroscience Society publishes original and significant review articles that explore the intersection between neuroscience and the study of psychological processes and behavior. The journal also welcomes articles that primarily focus on psychological processes and behavior, as long as they have relevance to one or more areas of neuroscience.