Relationships between cognitive flexibility performance and adaptive behavior outcomes in survivors of pediatric brain tumor.

IF 3 3区心理学 Q2 CLINICAL NEUROLOGY

Clinical Neuropsychologist Pub Date : 2024-06-30 DOI:10.1080/13854046.2024.2361967

Kylie A Szymanski, Jordan E Pincus, Tricia Z King

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引用次数: 0

Abstract

Objective: Survivors of pediatric brain tumors are at increased risk of executive function (EF) and adaptive behavior difficulties. While previous research suggests that executive dysfunction impacts suboptimal adaptive outcomes, the specific elements of EF influencing this relationship remain unexplored. This study examines the relationship between cognitive flexibility and adaptive behavior in survivors compared to healthy controls. Methods: 86 survivors (M_age(SD)=23.41(4.24), 44 females) and 86 controls (M_age(SD)=23.09(4.50), 44 females) completed the Delis-Kaplan Executive Function System Trail Making Test (TMT) and Verbal Fluency Test (VFT). The Letter-Number Sequencing (LNS) and Category Switching (CS) conditions were isolated as measures of cognitive flexibility. Informants provided responses to obtain adaptive behavior ratings using the Scales of Independent Behavior-Revised (SIB-R). Linear regressions explored relationships between cognitive flexibility and SIB-R scores in survivors compared to controls. Results: For both TMT and VFT, the relationship between cognitive flexibility and adaptive behavior was significantly different between survivors and controls for SIB-R scores in Social Communication, Community Living, and Personal Living Skills (p<.0125). Survivors' better LNS performance predicted greater SIB-R scores across the same 3 domains (all p= <.001, r²semipartial=.08). Similarly, survivors' better CS performance predicted greater SIB-R scores across the same 3 domains (p = 0.002 to .02, r²semipartial =.03 to .04). No significant relationships were found in controls (all p >.05). After adjusting for working memory and inhibitory control, most relationships remained significant in survivors (p= <.001 to .046, r²semipartial=.02 to .08). Conclusion: These findings reveal a robust, positive relationship between cognitive flexibility performance and adaptive behaviors specific to survivors.

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小儿脑肿瘤幸存者的认知灵活性表现与适应行为结果之间的关系。

目的：小儿脑肿瘤幸存者出现执行功能（EF）和适应行为障碍的风险增加。虽然以往的研究表明，执行功能障碍会影响次优的适应结果，但影响这种关系的EF的具体因素仍未得到探讨。本研究探讨了幸存者与健康对照组相比认知灵活性与适应行为之间的关系。方法：86 名幸存者（平均年龄（SD）=23.41（4.24），44 名女性）和 86 名对照组（平均年龄（SD）=23.09（4.50），44 名女性）完成了德利斯-卡普兰执行功能系统寻迹测试（TMT）和言语流畅性测试（VFT）。字母-数字排序（LNS）和类别转换（CS）条件被单独作为认知灵活性的测量项目。信息提供者通过独立行为量表-修订版（SIB-R）对适应行为进行评分。与对照组相比，线性回归探讨了幸存者认知灵活性与 SIB-R 评分之间的关系。结果：对于 TMT 和 VFT，幸存者和对照组在社会交流、社区生活和个人生活技能方面的 SIB-R 分数，认知灵活性和适应行为之间的关系存在显著差异（pp= r2semipartial=.08）。同样，幸存者更好的 CS 表现也预示着他们在这三个领域的 SIB-R 得分更高（p = 0.002 至 0.02，r2semipartial = 0.03 至 0.04）。在对照组中没有发现明显的关系（所有 p >.05）。在对工作记忆和抑制控制进行调整后，幸存者的大多数关系仍然显著（p= r2semipartial=.02至.08）。结论这些研究结果表明，认知灵活性表现与幸存者特有的适应行为之间存在稳健的正相关关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Neuropsychologist 医学-临床神经学

CiteScore

8.40

自引率

12.80%

发文量

审稿时长

6-12 weeks

期刊介绍： The Clinical Neuropsychologist (TCN) serves as the premier forum for (1) state-of-the-art clinically-relevant scientific research, (2) in-depth professional discussions of matters germane to evidence-based practice, and (3) clinical case studies in neuropsychology. Of particular interest are papers that can make definitive statements about a given topic (thereby having implications for the standards of clinical practice) and those with the potential to expand today’s clinical frontiers. Research on all age groups, and on both clinical and normal populations, is considered.