Shift from Cow's Milk Food Protein-Induced Enterocolitis Syndrome to IgE-Mediated Allergy: Case Series and Literature Review.

IF 1.1 4区 医学 Q4 ALLERGY
Simona Barni, Benedetta Pessina, Viktória Tóth, Lucrezia Sarti, Giulia Liccioli, Leonardo Tomei, Mattia Giovannini, Francesca Mori
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引用次数: 0

Abstract

Background: Food protein-induced enterocolitis syndrome (FPIES) is a non-IgE-mediated food allergy characterized by gastrointestinal symptom onset within 1-4 hours from trigger food ingestion. In the literature, some authors have previously described the possibility that a patient with FPIES may develop an IgE-mediated allergy to the same trigger food, especially cow's milk (CM). Case Presentation: We reported five cases of CM-FPIES converting to IgE-mediated CM allergy presented at our tertiary pediatric Allergy Unit and performed a review of the literature, aiming to characterize the clinical features of patients who are at risk of developing such conversion. Conclusions: This phenomenon raises the question of whether IgE-mediated and non-IgE-mediated allergies represent a spectrum of the same disease and highlights the need for further investigation to understand the pathophysiological mechanisms of this process.

从牛奶食物蛋白诱发的小肠结肠炎综合征转变为 IgE 引起的过敏:病例系列和文献综述。
背景:食物蛋白诱发小肠结肠炎综合征(FPIES)是一种非 IgE 介导的食物过敏,其特征是在摄入诱发食物后 1-4 小时内出现胃肠道症状。在文献中,一些作者曾描述过 FPIES 患者可能会对同一种诱发食物(尤其是牛奶 (CM))产生 IgE 介导的过敏。病例介绍:我们报告了五例在本院三级儿科过敏科就诊的 CM-FPIES 转为 IgE 介导的 CM 过敏的病例,并对文献进行了综述,旨在了解有可能发生此类转归的患者的临床特征。结论:这一现象提出了一个问题,即免疫球蛋白是否会导致中药过敏?这一现象提出了一个问题:IgE介导的过敏和非 IgE 介导的过敏是否代表了同一种疾病的一个谱系,并强调了进一步研究以了解这一过程的病理生理机制的必要性。
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来源期刊
CiteScore
2.00
自引率
0.00%
发文量
23
审稿时长
>12 weeks
期刊介绍: Pediatric Allergy, Immunology, and Pulmonology is a peer-reviewed journal designed to promote understanding and advance the treatment of respiratory, allergic, and immunologic diseases in children. The Journal delivers original translational, clinical, and epidemiologic research on the most common chronic illnesses of children—asthma and allergies—as well as many less common and rare diseases. It emphasizes the developmental implications of the morphological, physiological, pharmacological, and sociological components of these problems, as well as the impact of disease processes on families. Pediatric Allergy, Immunology, and Pulmonology coverage includes: -Functional and genetic immune deficiencies- Interstitial lung diseases- Both common and rare respiratory, allergic, and immunologic diseases- Patient care- Patient education research- Public health policy- International health studies
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