Associations of ultraprocessed food consumption with mortality among participants with a history of cancer: a prospective cohort analysis

IF 6.5 1区医学 Q1 NUTRITION & DIETETICS

American Journal of Clinical Nutrition Pub Date : 2024-09-01 DOI:10.1016/j.ajcnut.2024.06.010

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引用次数: 0

Abstract

Background

Although high ultraprocessed food (UPF) consumption has been linked with increased mortality risk in the general population, whether UPFs harm participants with a history of cancer remains unclear.

Objectives

This study aimed to evaluate the association of UPF consumption with mortality among participants with a history of cancer.

Methods

Prospective cohort analysis was conducted on 13,640 participants with a history of cancer from the UK Biobank. UPFs were defined by the Nova classification. UPF consumption was calculated as the weight proportion of UPFs in the total food consumption. Cox proportional hazard models were used to assess the association between UPF consumption and mortality among participants with a history of cancer.

Results

The median UPF consumption was 29.25% (interquartile range [IQR]: 19.46%–40.62%) for males and 25.81% (IQR: 16.61%–36.35%) for females in the total diet among participants with a history of cancer. During a median follow-up of 10.77 years, 1611 deaths were documented. Multivariable-adjusted hazard ratios (95% confidence intervals) among participants in the highest quartile of UPF consumption relative to the lowest were 1.17 (1.02, 1.35) for all-cause mortality and 1.22 (1.03, 1.44) for cancer-related mortality.

Conclusions

Higher UPF consumption after the diagnosis among participants with a history of cancer is associated with higher risk of mortality.

查看原文本刊更多论文

有癌症病史的参与者食用超加工食品与死亡率的关系：前瞻性队列分析。

背景：尽管超强加工食品（UPF）的高消费量与普通人群死亡风险的增加有关，但超强加工食品是否会对有癌症病史的参与者造成伤害仍不清楚：本研究旨在评估UPF摄入量与有癌症病史者死亡率的关系：对英国生物库中的 13640 名曾患癌症的参与者进行了前瞻性队列分析。UPF根据Nova分类法进行定义。UPF消耗量按UPF在总食物消耗量中的重量比例计算。采用Cox比例危险模型评估UPF消耗量与有癌症病史的参与者死亡率之间的关系：结果：在有癌症病史的参与者中，UPF摄入量的中位数为：男性占总膳食的29.25%（四分位数间距：19.46%-40.62%），女性占25.81%（四分位数间距：16.61%-36.35%）。在 10.77 年的中位随访期间，共记录了 1611 例死亡病例。经多变量调整后，UPF摄入量最高四分位数的参与者相对于最低四分位数的参与者的全因死亡率和癌症死亡率的危险比（95%置信区间）分别为1.17（1.02，1.35）和1.22（1.03，1.44）：结论：有癌症病史的参与者在确诊后摄入较多的 UPF 与较高的死亡风险有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American Journal of Clinical Nutrition 医学-营养学

CiteScore

12.40

自引率

4.20%

发文量

332

审稿时长

38 days

期刊介绍： American Journal of Clinical Nutrition is recognized as the most highly rated peer-reviewed, primary research journal in nutrition and dietetics.It focuses on publishing the latest research on various topics in nutrition, including but not limited to obesity, vitamins and minerals, nutrition and disease, and energy metabolism. Purpose: The purpose of AJCN is to: Publish original research studies relevant to human and clinical nutrition. Consider well-controlled clinical studies describing scientific mechanisms, efficacy, and safety of dietary interventions in the context of disease prevention or health benefits. Encourage public health and epidemiologic studies relevant to human nutrition. Promote innovative investigations of nutritional questions employing epigenetic, genomic, proteomic, and metabolomic approaches. Include solicited editorials, book reviews, solicited or unsolicited review articles, invited controversy position papers, and letters to the Editor related to prior AJCN articles. Peer Review Process: All submitted material with scientific content undergoes peer review by the Editors or their designees before acceptance for publication.