Life's Essential 8 and risks of cardiovascular morbidity and mortality among individuals with type 2 diabetes: A cohort study

IF 4.3 Q1 ENDOCRINOLOGY & METABOLISM

Diabetes & Metabolic Syndrome-Clinical Research & Reviews Pub Date : 2024-06-01 DOI:10.1016/j.dsx.2024.103066

Hanzhang Wu , Jiahe Wei , Shuai Wang , Wenjuan Chen , Liangkai Chen , Jihui Zhang , Ningjian Wang , Xiao Tan

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Abstract

Background

The association of cardiovascular health levels, as measured by the Life's Essential 8 score, with cardiovascular disease (CVD) incidence and mortality among individuals with type 2 diabetes (T2D) has not been fully elucidated.

Methods

This cohort study included 15,118 participants with T2D from the UK Biobank who were free of CVD and cancer at baseline. The cardiovascular health of participants was evaluated using the Life's Essential 8 score, categorizing their health levels into low, moderate, and high based on this assessment.

Results

During a median follow-up period of 13.0 years, we observed a total of 4421 cases of CVD, comprising 3467 cases of coronary heart disease (CHD), 811 cases of stroke, 1465 cases of heart failure (HF), and 523 cases of CVD mortality. Compared to participants with low cardiovascular health, those with high cardiovascular health had a 52 %, 50 %, 47 %, 67 %, and 51 % lower risk of CVD, CHD, stroke, HF, and CVD mortality, respectively. Among the components of the Life's Essential 8 score, body mass index showed the highest population attributable risk of 12.1 %. Similar findings were observed in joint analyses of cardiovascular health and diabetes severity status.

Conclusions

This study emphasizes the importance of maintaining good cardiovascular health among individuals with T2D to reduce their risk of CVD incidence and mortality.

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生活必备 8》与 2 型糖尿病患者的心血管发病率和死亡率风险：一项队列研究。

背景：在 2 型糖尿病（T2D）患者中，心血管健康水平（以生命必备 8 项评分衡量）与心血管疾病（CVD）发病率和死亡率之间的关系尚未完全阐明：这项队列研究包括英国生物库中的 15118 名 2 型糖尿病患者，他们在基线时没有心血管疾病和癌症。研究人员使用 "生命必备 8 "评分标准对参与者的心血管健康状况进行了评估，并根据评估结果将他们的健康水平分为低、中、高三个等级：在中位 13.0 年的随访期间，我们共观察到 4421 例心血管疾病，其中包括 3467 例冠心病（CHD）、811 例中风、1465 例心力衰竭（HF）和 523 例心血管疾病死亡。与心血管健康水平低的参与者相比，心血管健康水平高的参与者患心血管疾病、冠心病、中风、心力衰竭和心血管疾病死亡的风险分别低 52%、50%、47%、67% 和 51%。在 "生命必备 8 要素 "的各组成部分中，体重指数显示的人群归因风险最高，为 12.1%。在对心血管健康和糖尿病严重程度进行联合分析时也观察到了类似的结果：这项研究强调了保持 T2D 患者良好的心血管健康对降低其心血管疾病发病率和死亡率风险的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetes & Metabolic Syndrome-Clinical Research & Reviews ENDOCRINOLOGY & METABOLISM-

CiteScore

22.90

自引率

2.00%

发文量

248

审稿时长

51 days

期刊介绍： Diabetes and Metabolic Syndrome: Clinical Research and Reviews is the official journal of DiabetesIndia. It aims to provide a global platform for healthcare professionals, diabetes educators, and other stakeholders to submit their research on diabetes care. Types of Publications: Diabetes and Metabolic Syndrome: Clinical Research and Reviews publishes peer-reviewed original articles, reviews, short communications, case reports, letters to the Editor, and expert comments. Reviews and mini-reviews are particularly welcomed for areas within endocrinology undergoing rapid changes.