Drug repurposing: A multi targetted approach to treat cardiac disease from existing classical drugs to modern drug discovery.

3区 生物学 Q2 Biochemistry, Genetics and Molecular Biology
Shyam Tripathi, Kusum Rani, V Samuel Raj, Rashmi K Ambasta
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引用次数: 0

Abstract

Cardiovascular diseases (CVDs) are characterized by abnormalities in the heart, blood vessels, and blood flow. CVDs comprise a diverse set of health issues. There are several types of CVDs like stroke, endothelial dysfunction, thrombosis, atherosclerosis, plaque instability and heart failure. Identification of a new drug for heart disease takes longer duration and its safety efficacy test takes even longer duration of research and approval. This chapter explores drug repurposing, nano-therapy, and plant-based treatments for managing CVDs from existing drugs which saves time and safety issues with testing new drugs. Existing drugs like statins, ACE inhibitor, warfarin, beta blockers, aspirin and metformin have been found to be useful in treating cardiac disease. For better drug delivery, nano therapy is opening new avenues for cardiac research by targeting interleukin (IL), TNF and other proteins by proteome interactome analysis. Nanoparticles enable precise delivery to atherosclerotic plaques, inflammation areas, and damaged cardiac tissues. Advancements in nano therapeutic agents, such as drug-eluting stents and drug-loaded nanoparticles are transforming CVDs management. Plant-based treatments, containing phytochemicals from Botanical sources, have potential cardiovascular benefits. These phytochemicals can mitigate risk factors associated with CVDs. The integration of these strategies opens new avenues for personalized, effective, and minimally invasive cardiovascular care. Altogether, traditional drugs, phytochemicals along with nanoparticles can revolutionize the future cardiac health care by identifying their signaling pathway, mechanism and interactome analysis.

药物再利用:从现有经典药物到现代药物发现,治疗心脏病的多靶点方法。
心血管疾病(CVD)的特征是心脏、血管和血流出现异常。心血管疾病包括多种多样的健康问题。心血管疾病有多种类型,如中风、内皮功能障碍、血栓形成、动脉粥样硬化、斑块不稳定和心力衰竭。确定一种治疗心脏病的新药需要较长的时间,而对其安全性和有效性的测试则需要更长的研究和审批时间。本章探讨了从现有药物中提取治疗心血管疾病的药物再利用、纳米疗法和植物疗法,以节省测试新药的时间和安全问题。他汀类药物、血管紧张素转换酶抑制剂、华法林、β受体阻滞剂、阿司匹林和二甲双胍等现有药物已被证明可用于治疗心脏病。为了更好地给药,纳米疗法通过蛋白质组交互组分析瞄准白细胞介素(IL)、TNF 和其他蛋白质,为心脏研究开辟了新途径。纳米颗粒能够精确地向动脉粥样硬化斑块、炎症区域和受损的心脏组织输送药物。纳米治疗剂(如药物洗脱支架和载药纳米粒子)的进步正在改变心血管疾病的治疗。含有植物来源的植物化学物质的植物疗法对心血管具有潜在的益处。这些植物化学物质可以减轻与心血管疾病相关的风险因素。这些策略的整合为个性化、有效和微创的心血管治疗开辟了新途径。总之,传统药物、植物化学物质和纳米粒子可以通过确定其信号通路、机制和相互作用组分析,彻底改变未来的心脏保健。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
6.90
自引率
0.00%
发文量
0
审稿时长
>12 weeks
期刊介绍: Progress in Molecular Biology and Translational Science (PMBTS) provides in-depth reviews on topics of exceptional scientific importance. If today you read an Article or Letter in Nature or a Research Article or Report in Science reporting findings of exceptional importance, you likely will find comprehensive coverage of that research area in a future PMBTS volume.
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