Pemphigus oral lesions area index (POLAI): A new scoring scale for assessing oral pemphigus vulgaris.

IF 2.9 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Oral diseases Pub Date : 2025-01-01 Epub Date: 2024-06-27 DOI:10.1111/odi.15054

Fei Wang, Xuefeng Zhang, Yihuan Yao, Jiongke Wang, Yujie Shi, Tiannan Liu, Hao Xu, Yu Zhou, Hongxia Dan, Xin Zeng

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引用次数: 0

Abstract

Objectives: Current scales for Pemphigus vulgaris (PV) do not adequately represent the clinical variability of oral lesions. This study aimed to develop an independent scale, the Pemphigus Oral Lesions Area Index (POLAI), for assessment of oral PV exclusively, and compare POLAI, Pemphigus Disease Area Index (PDAI), Autoimmune Bullous Skin Disorder Intensity Score (ABSIS) and Oral Disease Severity Score (ODSS) regarding inter- and intra-observer reliability and validity.

Materials and methods: Retrospective cohort included 209 sets of digital-photographs. Additional clinical cohort included 32 PV patients. All visits were assessed by four clinicians using the PDAI, ABSIS, ODSS and POLAI, and were rated by three specialists using the Physician's Global Assessment (PGA).

Results: The intraclass correlation coefficient showed the inter-observer reliability with 0.89 and 0.86 for PDAI, 0.87 for ABSIS, 0.93 for ODSS, 0.96 for POLAI, and 0.97 and 0.96 for PGA. Intra-observer agreements showed excellent reliability for all 4 scores. Highest correlation was observed between PGA and POLAI (correlation coefficients were 0.96). The mean time taken to complete each scale was within 1.5 min.

Conclusion: POLAI is valid for the assessment of oral PV with superior inter- and intra-observer reliability to PDAI, ABSIS and ODSS, and is feasible in clinic.

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天疱疮口腔皮损面积指数（POLAI）：用于评估寻常型口腔天疱疮的新评分标准。

目的：目前针对寻常型天疱疮（PV）的量表不能充分反映口腔病变的临床变异性。本研究旨在开发一种独立的量表--天疱疮口腔病变面积指数（POLAI），专门用于评估口腔天疱疮，并比较POLAI、天疱疮病变面积指数（PDAI）、自身免疫性牛皮癣皮肤病强度评分（ABSIS）和口腔疾病严重程度评分（ODSS）在观察者之间和观察者内部的信度和效度：回顾性队列包括 209 套数字照片。额外的临床队列包括 32 名 PV 患者。所有访视均由四位临床医生使用 PDAI、ABSIS、ODSS 和 POLAI 进行评估，并由三位专家使用医师总体评估（PGA）进行评分：类内相关系数显示观察者之间的可靠性分别为：PDAI 0.89 和 0.86，ABSIS 0.87，ODSS 0.93，POLAI 0.96，PGA 0.97 和 0.96。所有 4 项评分的观察者内部一致性均显示出极佳的可靠性。PGA 和 POLAI 的相关性最高（相关系数为 0.96）。完成每个量表所需的平均时间在 1.5 分钟以内：结论：POLAI 是评估口腔 PV 的有效方法，与 PDAI、ABSIS 和 ODSS 相比，其观察者之间和观察者内部的可靠性更高，在临床上也是可行的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oral diseases 医学-牙科与口腔外科

CiteScore

7.60

自引率

5.30%

发文量

325

审稿时长

4-8 weeks

期刊介绍： Oral Diseases is a multidisciplinary and international journal with a focus on head and neck disorders, edited by leaders in the field, Professor Giovanni Lodi (Editor-in-Chief, Milan, Italy), Professor Stefano Petti (Deputy Editor, Rome, Italy) and Associate Professor Gulshan Sunavala-Dossabhoy (Deputy Editor, Shreveport, LA, USA). The journal is pre-eminent in oral medicine. Oral Diseases specifically strives to link often-isolated areas of dentistry and medicine through broad-based scholarship that includes well-designed and controlled clinical research, analytical epidemiology, and the translation of basic science in pre-clinical studies. The journal typically publishes articles relevant to many related medical specialties including especially dermatology, gastroenterology, hematology, immunology, infectious diseases, neuropsychiatry, oncology and otolaryngology. The essential requirement is that all submitted research is hypothesis-driven, with significant positive and negative results both welcomed. Equal publication emphasis is placed on etiology, pathogenesis, diagnosis, prevention and treatment.