Histopathological risk assessment in multisite epithelial dysplasia: A meta-analysis.

IF 2.9 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Oral diseases Pub Date : 2024-11-01 Epub Date: 2024-06-30 DOI:10.1111/odi.15052

Daniel Lobato Ferreira Ferraz, Erison Santana Dos Santos, Caique Mariano Pedroso, Brunno Santos de Freitas Silva, Omar Kujan, Tuula Anneli Salo, Mohammed I Malki, Susanna Juteau, Pablo Agustin Vargas, Marcio Ajudarte Lopes, Alan Roger Santos-Silva

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引用次数: 0

Abstract

Objective: Histopathological grading of oral epithelial dysplasia (OED) is the current standard for stratifying cancer progression risk but is associated with subjectivity and variability. This problem is not commonly seen regarding the grading of epithelial dysplasia in other sites. This systematic review aims to compare grading systems for oral, anal, penile, and cervical epithelial dysplasia to determine their predictive accuracy for recurrence and malignant transformation (MT) outcomes.

Methods: The review protocol was registered in PROSPERO (CRD42023403035) and was reported according to the PRISMA checklist. A comprehensive search was performed in the main databases and gray literature. The risk of bias in individual studies was analyzed using the Joanna Briggs Institute checklist for each study design.

Results: Forty-six studies were deemed eligible and included in this systematic review, of which 45 were included in the quantitative analysis. Meta-analysis revealed that the binary system demonstrated a higher predictive ability for MT/recurrence of OED compared to multilevel systems. Higher predictive accuracy of MT was also observed for binary grading systems in anal intraepithelial neoplasia.

Conclusions: No significant difference was found between the current grading systems of epithelial dysplasia in different body parts. However, binary grading systems have shown better clinical outcomes.

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多部位上皮发育不良的组织病理学风险评估：一项荟萃分析。

目的：口腔上皮发育不良（OED）的组织病理学分级是目前癌症进展风险分层的标准，但与主观性和可变性有关。这一问题在其他部位上皮发育不良的分级中并不常见。本系统性综述旨在比较口腔、肛门、阴茎和宫颈上皮发育不良的分级系统，以确定其对复发和恶性转化（MT）结果的预测准确性：综述方案已在 PROSPERO（CRD42023403035）中注册，并按照 PRISMA 核对表进行报告。在主要数据库和灰色文献中进行了全面检索。采用乔安娜-布里格斯研究所（Joanna Briggs Institute）的核对表对每项研究设计的偏倚风险进行了分析：有 46 项研究被认为符合条件并纳入了本系统综述，其中 45 项纳入了定量分析。元分析显示，与多级系统相比，二元系统对MT/OED复发的预测能力更高。在肛门上皮内瘤变中，二元分级系统对MT的预测准确性也更高：结论：目前不同身体部位上皮发育不良的分级系统之间没有明显差异。然而，二元分级系统的临床效果更好。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oral diseases 医学-牙科与口腔外科

CiteScore

7.60

自引率

5.30%

发文量

325

审稿时长

4-8 weeks

期刊介绍： Oral Diseases is a multidisciplinary and international journal with a focus on head and neck disorders, edited by leaders in the field, Professor Giovanni Lodi (Editor-in-Chief, Milan, Italy), Professor Stefano Petti (Deputy Editor, Rome, Italy) and Associate Professor Gulshan Sunavala-Dossabhoy (Deputy Editor, Shreveport, LA, USA). The journal is pre-eminent in oral medicine. Oral Diseases specifically strives to link often-isolated areas of dentistry and medicine through broad-based scholarship that includes well-designed and controlled clinical research, analytical epidemiology, and the translation of basic science in pre-clinical studies. The journal typically publishes articles relevant to many related medical specialties including especially dermatology, gastroenterology, hematology, immunology, infectious diseases, neuropsychiatry, oncology and otolaryngology. The essential requirement is that all submitted research is hypothesis-driven, with significant positive and negative results both welcomed. Equal publication emphasis is placed on etiology, pathogenesis, diagnosis, prevention and treatment.