Bee venom as a promising therapeutic strategy in central nervous system diseases

IF 2.5 3区医学 Q3 ENDOCRINOLOGY & METABOLISM

Neuropeptides Pub Date : 2024-06-22 DOI:10.1016/j.npep.2024.102451

Zeinab Vahidinia , Shirin Barati , Abolfazl Azami Tameh , Saeid Bagheri-Mohammadi , Ali Garshasebi

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引用次数: 0

Abstract

Central nervous system (CNS) disorders are one of the leading health problems today, accounting for a large proportion of global morbidity and mortality. Most these disorders are characterized by high levels of oxidative stress and intense inflammatory responses in degenerated neuronal tissues. While extensive research has been conducted on CNS diseases, but few breakthroughs have been made in treatment methods. To date, there are no disease-modifying drugs available for CNS treatment, underscoring the urgent need for finding effective medications. Bee venom (BV), which is produced by honeybee workers' stingers, has been a subject of interest and study across various cultures. Over the past few decades, extensive research has focused on BV and its therapeutic potentials. BV consists a variety of substances, mainly proteins and peptides like melittin and phospholipase A2 (PLA2). Research has proven that BV is effective in various medical conditions, including pain, arthritis and inflammation and CNS disorders such as Multiple sclerosis, Alzheimer's disease and Parkinson's disease. This review provides a comprehensive overview of the existing knowledge concerning the therapeutic effects of BV and its primary compounds on various CNS diseases. Additionally, we aim to shed light on the potential cellular and molecular mechanisms underlying these effects.

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蜂毒是一种治疗中枢神经系统疾病的有效方法。

中枢神经系统（CNS）疾病是当今最主要的健康问题之一，在全球发病率和死亡率中占很大比例。大多数中枢神经系统疾病的特征是神经元组织变性后产生高水平的氧化应激和强烈的炎症反应。虽然人们对中枢神经系统疾病进行了广泛的研究，但在治疗方法上却鲜有突破。迄今为止，还没有治疗中枢神经系统疾病的药物，因此迫切需要找到有效的药物。蜂毒（BV）由蜜蜂工蜂的螫针产生，一直是各种文化感兴趣和研究的课题。在过去的几十年里，人们对蜂毒及其治疗潜力进行了广泛的研究。BV 由多种物质组成，主要是蛋白质和肽，如 Melittin 和磷脂酶 A2（PLA2）。研究证明，BV 对多种疾病有效，包括疼痛、关节炎、炎症和中枢神经系统疾病，如多发性硬化症、老年痴呆症和帕金森病。本综述全面概述了有关 BV 及其主要化合物对各种中枢神经系统疾病治疗效果的现有知识。此外，我们还旨在阐明这些作用的潜在细胞和分子机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuropeptides 医学-内分泌学与代谢

CiteScore

5.40

自引率

6.90%

发文量

审稿时长

>12 weeks

期刊介绍： The aim of Neuropeptides is the rapid publication of original research and review articles, dealing with the structure, distribution, actions and functions of peptides in the central and peripheral nervous systems. The explosion of research activity in this field has led to the identification of numerous naturally occurring endogenous peptides which act as neurotransmitters, neuromodulators, or trophic factors, to mediate nervous system functions. Increasing numbers of non-peptide ligands of neuropeptide receptors have been developed, which act as agonists or antagonists in peptidergic systems. The journal provides a unique opportunity of integrating the many disciplines involved in all neuropeptide research. The journal publishes articles on all aspects of the neuropeptide field, with particular emphasis on gene regulation of peptide expression, peptide receptor subtypes, transgenic and knockout mice with mutations in genes for neuropeptides and peptide receptors, neuroanatomy, physiology, behaviour, neurotrophic factors, preclinical drug evaluation, clinical studies, and clinical trials.