Alessandro Pezzini, Barbara Tarantino, Maria Luisa Zedde, Simona Marcheselli, Giorgio Silvestrelli, Alfonso Ciccone, Maria Luisa Delodovici, Lucia Princiotta Cariddi, Simone Vidale, Maurizio Paciaroni, Cristiano Azzini, Marina Padroni, Massimo Gamba, Mauro Magoni, Massimo Del Sette, Rossana Tassi, Ivo Giuseppe de Franco, Anna Cavallini, Rocco Salvatore Calabrò, Manuel Cappellari, Elisa Giorli, Giacomo Giacalone, Corrado Lodigiani, Mara Zenorini, Francesco Valletta, Rosario Pascarella, Giorgia Abrignani, Paola Castellini, Antonio Genovese, Lilia Latte, Maria Claudia Trapasso, Ilaria Grisendi, Federica Assenza, Manuela Napoli, Claudio Moratti, Sofia Beccattini, Maurizio Acampa, Franco Valzania, Mario Grassi, Davide Gentilini
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引用次数: 0
Abstract
Background: Whether statin use after spontaneous intracerebral haemorrhage (ICH) increases the risk of recurrent ICH is uncertain.
Methods: In the setting of the Multicentric Study on Cerebral Haemorrhage in Italy we followed up a cohort of 30-day ICH survivors, consecutively admitted from January 2002 to July 2014, to assess whether the use of statins after the acute event is associated with recurrent cerebral bleeding.
Results: 1623 patients (mean age, 73.9±10.3 years; males, 55.9%) qualified for the analysis. After a median follow-up of 40.5 months (25th to 75th percentile, 67.7) statin use was not associated with increased risk of recurrent ICH either in the whole study group (adjusted HR, 0.99; 95% CI 0.64 to 1.53) or in the subgroups defined by haematoma location (deep ICH, adjusted HR, 0.74; 95% CI 0.35 to 1.57; lobar ICH, adjusted HR, 1.09; 95% CI 0.62 to 1.90), intensity of statins (low-moderate intensity statins, adjusted HR, 0.93; 95% CI 0.58 to 1.49; high-intensity statins, adjusted HR, 1.48; 95% CI 0.66 to 3.31) and use of statins before the index event (adjusted HR, 0.66; 95% CI 0.38 to 1.17).
Conclusions: Statin use appears to be unrelated to the risk of ICH recurrence.
背景：自发性脑出血（ICH）后使用他汀类药物是否会增加ICH复发的风险尚不确定：方法：在意大利脑出血多中心研究的背景下，我们对2002年1月至2014年7月期间连续入院的30天ICH幸存者进行了队列随访，以评估急性事件后使用他汀类药物是否与复发性脑出血有关：1623名患者（平均年龄为73.9±10.3岁，男性占55.9%）符合分析条件。在中位随访 40.5 个月后（第 25 至 75 百分位数，67.7），无论是在整个研究组（调整后 HR，0.99；95% CI 0.64 至 1.53），还是在根据血肿位置定义的亚组（深部 ICH，调整后 HR，0.74；95% CI 0.35 至 1.57；叶状 ICH，调整后 HR，0.74），他汀类药物的使用都与复发性 ICH 风险的增加无关。57; lobar ICH, adjusted HR, 1.09; 95% CI 0.62 to 1.90）、他汀类药物的强度（低-中等强度他汀类药物，调整后HR，0.93；95% CI 0.58 to 1.49；高强度他汀类药物，调整后HR，1.48；95% CI 0.66 to 3.31）和指数事件前使用他汀类药物（调整后HR，0.66；95% CI 0.38 to 1.17）：他汀类药物的使用似乎与 ICH 复发风险无关。
期刊介绍：
The Journal of Neurology, Neurosurgery & Psychiatry (JNNP) aspires to publish groundbreaking and cutting-edge research worldwide. Covering the entire spectrum of neurological sciences, the journal focuses on common disorders like stroke, multiple sclerosis, Parkinson’s disease, epilepsy, peripheral neuropathy, subarachnoid haemorrhage, and neuropsychiatry, while also addressing complex challenges such as ALS. With early online publication, regular podcasts, and an extensive archive collection boasting the longest half-life in clinical neuroscience journals, JNNP aims to be a trailblazer in the field.
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