A new canthinone glycoside isolated from the root barks of Ailanthus altissima with NO inhibitory activity

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2024-06-28 DOI:10.1080/10286020.2024.2360047

引用次数: 0

Abstract

One new canthinone glycoside (1), together with six known compounds (2–7) including three lignans (2–4), two coumarins (5–6) and one phenol (7) was isolated from the root barks of Ailanthus altissima. The structure of new compound 1 was established by the interpretation of UV, IR, MS and NMR data, while its absolute configuration was determined by acid hydrolysis and GIAO NMR calculations with DP4+ probability analysis. The inhibitory effects of all compounds on Nitric oxide (NO) production were investigated in lipopolysaccharide (LPS)-induced RAW 264.7 cells. Results showed that compounds 2 and 5 displayed NO production inhibitory activity with IC₅₀ values of 30.1 and 15.3 μM, respectively.

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从具有 NO 抑制活性的 Ailanthus altissima 根皮中分离出一种新的 canthinone 苷。

从 Ailanthus altissima 的根皮中分离出了一种新的 canthinone 苷（1），以及六种已知化合物（2-7），包括三种木脂素（2-4）、两种香豆素（5-6）和一种酚（7）。通过解读紫外、红外、质谱和核磁共振数据，确定了新化合物 1 的结构；通过酸水解和 DP4+ 概率分析的 GIAO 核磁共振计算，确定了其绝对构型。在脂多糖（LPS）诱导的 RAW 264.7 细胞中，研究了所有化合物对一氧化氮（NO）产生的抑制作用。结果表明，化合物 2 和 5 具有抑制一氧化氮产生的活性，其 IC50 值分别为 30.1 和 15.3 μM。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.