Lack of association between serum apelin levels and sarcopenia in elderly malnourished subjects.

IF 3.3 4区医学 Q1 Medicine

European review for medical and pharmacological sciences Pub Date : 2024-06-01 DOI:10.26355/eurrev_202406_36461

D de Luis, D Primo, O Izaola, J J López Gómez

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引用次数: 0

Abstract

Objective: Sarcopenia is a condition characterized by muscle mass loss. Skeletal muscle is capable of producing and secreting different molecules called myokines, and apelin is one of them. The literature contains contradictory data on the relationship between apelin and sarcopenia. We decided to investigate the role of apelin in sarcopenia in subjects with disease-related malnutrition (DRM), a group of patients with a high rate of sarcopenia.

Patients and methods: 83 elderly patients with DRM assessed according to the Global Leadership Initiative on Malnutrition (GLIM) criteria were included in the study, with a mean age of 69.9±3.8 years. Anthropometric data, muscle mass by ultrasound at the rectus femoris quadriceps (RFQ) level, bioimpedance [skeletal muscle mass (SMM), appendicular SMM (aSMM) and aSMM index (aSMMI)], dynamometry, biochemical parameters, dietary intake, circulating apelin levels were determined in all patients.

Results: a total of 33 patients (37.9%) were diagnosed with sarcopenia, while 54 patients did not present sarcopenia (60.1%). Body weight (-5.5±2.0 kg, p=0.01), calf circumference (-1.9±0.2 cm, p=0.02), phase angle (-0.6±0.2º, p=0.01), reactance (-6.8±2.3 Ohms, p=0.03), resistance (-38.8±12.3 Ohms, p=0.04), SMM (-2.2±0.3 kg, p=0.04), aSMM (-2.2±0.2 kg, p=0.03) and aSMMI (-0.6±0.2 kg, p=0.02), dominant muscle area (-0.6±0.2 cm2, p=0.04), dominant Y axis (-0.4±0.1 cm, p=0.03), dominant X/Y axis (1.1±0.3 cm, p=0.04), strength (-5.1±1.3 kg, p=0.01), albumin (-0.9±0.1 g/dl, p=0.02) and prealbumin (-4.6±0.7 mg/dl, p=0.02) were worse in patients with sarcopenia than non-sarcopenic patients. Circulating apelin levels were similar in both groups. No significant correlation of apelin levels was detected, either with bioimpedance data or with muscle ultrasonography data. The multivariant analysis did not detect a significant association of apelin with the presence of sarcopenia.

Conclusions: Our study shows a lack of association between apelin and sarcopenia in elderly malnourished patients.

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老年营养不良者的血清凋亡素水平与肌肉疏松症之间缺乏关联。

目的肌肉疏松症是一种以肌肉量减少为特征的疾病。骨骼肌能够产生和分泌不同的分子，这些分子被称为肌动素，凋亡素就是其中之一。文献中关于凋亡素与肌肉疏松症之间关系的数据相互矛盾。我们决定研究凋亡磷脂在疾病相关营养不良症（DRM）患者肌少症中的作用，这类患者的肌少症发病率很高。研究人员对所有患者的人体测量数据、股直肌股四头肌（RFQ）水平超声肌肉质量、生物阻抗[骨骼肌质量（SMM）、阑尾SMM（aSMM）和aSMM指数（aSMMI）]、测力法、生化参数、饮食摄入量、循环凋亡素水平进行了测定。结果：共有 33 名患者（37.9%）被诊断为肌少症，54 名患者（60.1%）未出现肌少症。体重（-5.5±2.0 kg，p=0.01）、小腿围（-1.9±0.2 cm，p=0.02）、相角（-0.6±0.2º，p=0.01）、电抗（-6.8±2.3 Ohms，p=0.03）、电阻（-38.8±12.3 欧姆，p=0.04）、SMM（-2.2±0.3 千克，p=0.04）、aSMM（-2.2±0.2 千克，p=0.03）和 aSMMI（-0.6±0.2 千克，p=0.02）、优势肌肉面积（-0.6±0.2 cm2，p=0.04）、优势 Y 轴（-0.4±0.1 cm，p=0.03）、优势 X/Y 轴（1.1±0.3 cm，p=0.04）、力量（-5.1±1.3 kg，p=0.肌肉疏松症患者的白蛋白（-0.9±0.1 g/dl，p=0.02）和前白蛋白（-4.6±0.7 mg/dl，p=0.02）均比非肌肉疏松症患者差。两组患者的循环凋亡素水平相似。凋亡磷脂水平与生物阻抗数据或肌肉超声波数据均无明显相关性。多变量分析也未发现凋亡素与肌肉疏松症有明显关联：我们的研究表明，老年营养不良患者体内的凋亡磷脂与肌肉疏松症之间没有关联。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European review for medical and pharmacological sciences 医学-药学

CiteScore

5.30

自引率

6.10%

发文量

906

审稿时长

2-4 weeks

期刊介绍： European Review for Medical and Pharmacological Sciences, a fortnightly journal, acts as an information exchange tool on several aspects of medical and pharmacological sciences. It publishes reviews, original articles, and results from original research. The purposes of the Journal are to encourage interdisciplinary discussions and to contribute to the advancement of medicine. European Review for Medical and Pharmacological Sciences includes: -Editorials- Reviews- Original articles- Trials- Brief communications- Case reports (only if of particular interest and accompanied by a short review)