Seroprevalence of human immunodeficiency virus in African blood donors: a systematic review and meta-analysis.

IF 9.7 1区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

EBioMedicine Pub Date : 2024-07-01 Epub Date: 2024-06-28 DOI:10.1016/j.ebiom.2024.105210

Angelina Edna Quintas, Nelson Cuboia, Lemuel Cordeiro, António Sarmento, Luís Azevedo

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引用次数: 0

Abstract

Background: In developing countries, the safety of blood transfusions remains an important public health concern as it is associated with a higher risk of transfusion-transmissible infections (TTIs). In this study, we aimed to estimate the seroprevalence of HIV among blood donors in Africa and assess the temporal trends and regional differences within the continent through a systematic review and meta-analysis.

Methods: Seven electronic databases (PubMed, Web of Science, Cochrane, Scopus, HINARI, Global Index Medicus and Clinical.

Trial: gov) were searched for relevant studies for our research. We included all primary studies that estimated the seroprevalence of HIV among blood donors in Africa with an age population from 16 to 65 years old, without language restrictions, from inception up to March 1st 2024. The pooled seroprevalence was estimated through the DerSimonian-Laird random effects model. The temporal trends and regional differences were assessed through subgroup and meta-regression analysis.

Findings: We obtained 122 studies that met our inclusion criteria, comprising 7,814,996 blood donors tested for HIV. Sixty-six percent of the studies were from Western and Eastern Africa. The pooled seroprevalence of HIV among blood donors in Africa was 2.66% (95% CI: 2.17-3.20%; I² = 99.80%, p < 0.01). The highest prevalence was observed in the Central African region, 3.28% (95% CI: 2.57%-4.06%), followed by the Eastern 3.21% (95% CI: 2.12%-4.52%), and the Western 2.66% (95% CI: 1.93%-3.49%) regions. Lower prevalences were observed in the Northern region, 0.57% (95% CI: 0.0%-2.10%), followed by the Southern African region with 0.45% (95% CI: 0.16%-0.86%). We observed a temporal decreased trend of HIV prevalence.

Interpretation: The prevalence of HIV infection among African blood donors remains high and is not homogeneous across the continent. Efficient measures to strengthen HIV testing and prevent HIV transmission through blood transfusion are needed in Africa. Systematic review protocol registration: PROSPERO CRD42023395616.

Funding: This article was supported by National Funds through FCT - Fundação para a Ciência e a Tecnologia,I.P., within CINTESIS, R&D Unit (reference UIDP/4255/2020).

查看原文本刊更多论文

非洲献血者的人体免疫缺陷病毒血清流行率：系统回顾和荟萃分析。

背景：在发展中国家，输血的安全性仍然是一个重要的公共卫生问题，因为输血与较高的输血传播感染（TTIs）风险相关。在本研究中，我们旨在通过系统回顾和荟萃分析，估算非洲献血者的艾滋病毒血清流行率，并评估非洲大陆的时间趋势和地区差异：搜索了七个电子数据库（PubMed、Web of Science、Cochrane、Scopus、HINARI、Global Index Medicus 和 Clinical.Trial:gov）中与我们的研究相关的研究。我们收录了所有估算非洲献血者艾滋病毒血清流行率的主要研究，这些研究的年龄范围为 16 岁至 65 岁，没有语言限制，研究时间从开始至 2024 年 3 月 1 日。通过 DerSimonian-Laird 随机效应模型估算了汇总血清流行率。通过亚组和元回归分析评估了时间趋势和地区差异：我们获得了 122 项符合纳入标准的研究，包括 7,814,996 名接受 HIV 检测的献血者。66%的研究来自非洲西部和东部。非洲献血者中艾滋病病毒感染血清阳性率为 2.66%（95% CI：2.17-3.20%；I2 = 99.80%，P 解释：非洲献血者中艾滋病病毒感染血清阳性率为 2.66%（95% CI：2.17-3.20%）：非洲献血者中的 HIV 感染率仍然很高，而且在整个非洲大陆并不均衡。非洲需要采取有效措施，加强 HIV 检测，防止 HIV 通过输血传播。系统综述协议注册：PROSPERO CRD42023395616.Funding:本文由 FCT - Fundação para a Ciência e a Tecnologia,I.P., CINTESIS, R&D Unit（编号 UIDP/4255/2020）提供的国家基金资助。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

EBioMedicine Biochemistry, Genetics and Molecular Biology-General Biochemistry,Genetics and Molecular Biology

CiteScore

17.70

自引率

0.90%

发文量

579

审稿时长

5 weeks

期刊介绍： eBioMedicine is a comprehensive biomedical research journal that covers a wide range of studies that are relevant to human health. Our focus is on original research that explores the fundamental factors influencing human health and disease, including the discovery of new therapeutic targets and treatments, the identification of biomarkers and diagnostic tools, and the investigation and modification of disease pathways and mechanisms. We welcome studies from any biomedical discipline that contribute to our understanding of disease and aim to improve human health.

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