Biofabrication strategies for cardiac tissue engineering

IF 7.1 2区 工程技术 Q1 BIOCHEMICAL RESEARCH METHODS
Sargol Okhovatian , Ramak Khosravi , Erika Y Wang , Yimu Zhao , Milica Radisic
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引用次数: 0

Abstract

Biofabrication technologies hold the potential to provide high-throughput, easy-to-operate, and cost-effective systems that recapitulate complexities of the native heart. The size of the fabricated model, printing resolution, biocompatibility, and ease-of-fabrication are some of the major parameters that can be improved to develop more sophisticated cardiac models. Here, we review recent cardiac engineering technologies ranging from microscaled organoids, millimeter-scaled heart-on-a-chip platforms, in vitro ventricle models sized to the fetal heart, larger cardiac patches seeded with billions of cells, and associated biofabrication technologies used to produce these models. Finally, advancements that facilitate model translation are discussed, such as their application as carriers for bioactive components and cells in vivo or their capability for drug testing and disease modeling in vitro.

心脏组织工程的生物制造策略。
生物制造技术具有提供高通量、易操作和高成本效益系统的潜力,可再现原生心脏的复杂性。制造模型的尺寸、打印分辨率、生物相容性和制造难易程度是开发更复杂的心脏模型可以改进的一些主要参数。在此,我们回顾了最新的心脏工程技术,包括显微镜下的器官组织、毫米级芯片上的心脏平台、与胎儿心脏大小相当的体外心室模型、种有数十亿细胞的更大心脏补片,以及用于制造这些模型的相关生物制造技术。最后,还讨论了促进模型转化的先进技术,如在体内作为生物活性成分和细胞载体的应用,或在体外进行药物测试和疾病建模的能力。
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来源期刊
Current opinion in biotechnology
Current opinion in biotechnology 工程技术-生化研究方法
CiteScore
16.20
自引率
2.60%
发文量
226
审稿时长
4-8 weeks
期刊介绍: Current Opinion in Biotechnology (COBIOT) is renowned for publishing authoritative, comprehensive, and systematic reviews. By offering clear and readable syntheses of current advances in biotechnology, COBIOT assists specialists in staying updated on the latest developments in the field. Expert authors annotate the most noteworthy papers from the vast array of information available today, providing readers with valuable insights and saving them time. As part of the Current Opinion and Research (CO+RE) suite of journals, COBIOT is accompanied by the open-access primary research journal, Current Research in Biotechnology (CRBIOT). Leveraging the editorial excellence, high impact, and global reach of the Current Opinion legacy, CO+RE journals ensure they are widely read resources integral to scientists' workflows. COBIOT is organized into themed sections, each reviewed once a year. These themes cover various areas of biotechnology, including analytical biotechnology, plant biotechnology, food biotechnology, energy biotechnology, environmental biotechnology, systems biology, nanobiotechnology, tissue, cell, and pathway engineering, chemical biotechnology, and pharmaceutical biotechnology.
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