Genitourinary infection and gastroschisis: A systematic review and meta-analysis

IF 1.6 4区医学 Q4 DEVELOPMENTAL BIOLOGY

Birth Defects Research Pub Date : 2024-06-30 DOI:10.1002/bdr2.2377

Raya Vinogradov, Annie Muthupunnackal, Malcolm Moffat, Judith Rankin

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引用次数: 0

Abstract

Background

Gastroschisis is a congenital anomaly of the umbilical ring with increasing prevalence, especially amongst younger mothers. There is increasing evidence that exposure to genitourinary infections (GUTI) may play an important role in the etiology of gastroschisis. This systematic review and meta-analysis aimed to identify, appraise, and summarize the literature on exposure to GUTI and gastroschisis.

Methods

Six electronic databases (MEDLINE, EMBASE, Web of Science, Scopus, Cochrane Library electronic databases, and Prospero) were searched using a comprehensive search strategy. Citations and cited articles for all included studies were searched. Peer-reviewed, quantitative studies reporting an association of urinary tract infections (UTI) and/or sexually transmitted infections (STI) with gastroschisis were included. Prospero registration CRD42022377420.

Results

A total of 2392 papers were identified via the searches of which 15 met our inclusion criteria and were included after title and abstract and full text screening. The study period for included studies ranged from 1995 to 2016, most were from the USA. Four studies considering exposure to STIs and five to UTIs were eligible to progress to meta-analysis. Meta-analysis identified a significantly increased risk of gastroschisis in association with periconceptional exposure to UTI [OR 1.54 (95% CI 1.29, 1.8)], STI [OR 1.4 (95% CI 1.01, 1.79)].

Conclusions

Periconceptional exposure to GUTI is associated with an increased risk of gastroschisis. The prevention and timely treatment of GUTI amongst women of childbearing age may help to reduce the occurrence of gastroschisis.

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查看原文本刊更多论文

泌尿生殖系统感染与胃畸形：系统回顾和荟萃分析。

背景：胃裂是一种先天性脐环畸形，发病率越来越高，尤其是在年轻母亲中。越来越多的证据表明，泌尿生殖系统感染（GUTI）可能在胃螺裂的病因中扮演重要角色。本系统综述和荟萃分析旨在识别、评估和总结有关接触泌尿生殖系统感染和胃畸形的文献：采用综合检索策略检索了六个电子数据库（MEDLINE、EMBASE、Web of Science、Scopus、Cochrane 图书馆电子数据库和 Prospero）。对所有纳入研究的引文和引用文章进行了检索。纳入了经同行评议、报告尿路感染 (UTI) 和/或性传播感染 (STI) 与胃螺裂相关性的定量研究。Prospero 注册号为 CRD42022377420：通过检索共发现 2392 篇论文，其中 15 篇符合我们的纳入标准，经过标题、摘要和全文筛选后被纳入。纳入研究的研究时间从 1995 年到 2016 年不等，大多数研究来自美国。其中四项研究考虑了性传播感染的风险，五项研究考虑了UTI的风险，符合荟萃分析的条件。荟萃分析发现，围孕期接触UTI[OR 1.54 (95% CI 1.29, 1.8)]和STI[OR 1.4 (95% CI 1.01, 1.79)]会显著增加胃畸形的风险：围孕期感染 GUTI 与胃螺裂风险增加有关。育龄妇女预防和及时治疗 GUTI 可能有助于减少胃畸形的发生。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Birth Defects Research Medicine-Embryology

CiteScore

3.60

自引率

9.50%

发文量

153

期刊介绍： The journal Birth Defects Research publishes original research and reviews in areas related to the etiology of adverse developmental and reproductive outcome. In particular the journal is devoted to the publication of original scientific research that contributes to the understanding of the biology of embryonic development and the prenatal causative factors and mechanisms leading to adverse pregnancy outcomes, namely structural and functional birth defects, pregnancy loss, postnatal functional defects in the human population, and to the identification of prenatal factors and biological mechanisms that reduce these risks. Adverse reproductive and developmental outcomes may have genetic, environmental, nutritional or epigenetic causes. Accordingly, the journal Birth Defects Research takes an integrated, multidisciplinary approach in its organization and publication strategy. The journal Birth Defects Research contains separate sections for clinical and molecular teratology, developmental and reproductive toxicology, and reviews in developmental biology to acknowledge and accommodate the integrative nature of research in this field. Each section has a dedicated editor who is a leader in his/her field and who has full editorial authority in his/her area.