The effects of killer cell immunoglobulin-like receptor (KIR) genes on susceptibility to severe COVID-19 in the Iranian population.

IF 2.9 4区 医学 Q3 IMMUNOLOGY
Narges Karami, Shaghik Barani, Mona Fani, Seppo Meri, Reza Shafiei, Kurosh Kalantar
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Abstract

Background: Variations in the innate and adaptive immune response systems are linked to variations in the severity of COVID-19. Natural killer cell (NK) function is regulated by sophisticated receptor system including Killer-cell immunoglobulin-like receptor (KIR) family. We aimed to investigate the impact of possessing certain KIR genes and genotypes on COVID19 severity in Iranians. KIR genotyping was performed on 394 age/sex matched Iranians with no underlying conditions who developed mild and severe COVID- 19. The presence and/or absence of 11 KIR genes were determined using the PCR with sequence specific primers (PCR-SSP).

Results: Patients with mild symptoms had higher frequency ofKIR2DS1 (p = 0.004) and KIR2DS2 (p = 0.017) genes compared to those with severe disease. While KIR3DL3 and deleted variant of KIR2DS4 occurred more frequently in patients who developed a severe form of the disease. In this study, a significant increase of and B haplotype was observed in the Mild group compared to the Severe group (respectively, p = 0.002 and p = 0.02). Also, the prevalence of haplotype A was significantly higher in the Severe group than in the Mild group (p = 0.02).

Conclusions: These results suggest that the KIR2DS1, KIR2DS, and B haplotype maybe have a protective effect against COVID-19 severity. The results also suggest the inhibitory gene KIR2DL3 and haplotype A are risk factors for the severity of COVID-19.

伊朗人群中杀伤细胞免疫球蛋白样受体(KIR)基因对重症 COVID-19 易感性的影响。
背景:先天性和适应性免疫反应系统的变化与 COVID-19 严重程度的变化有关。自然杀伤细胞(NK)的功能受到包括杀伤细胞免疫球蛋白样受体(KIR)家族在内的复杂受体系统的调控。我们的目的是调查拥有某些 KIR 基因和基因型对伊朗人 COVID19 严重程度的影响。我们对 394 名年龄/性别匹配的伊朗人进行了 KIR 基因分型,这些人没有任何潜在疾病,但都患上了轻度和重度 COVID- 19。使用序列特异性引物 PCR(PCR-SSP)测定了 11 个 KIR 基因的存在和/或缺失情况:结果:与重症患者相比,轻症患者的 KIR2DS1(p = 0.004)和 KIR2DS2(p = 0.017)基因频率较高。而 KIR3DL3 和 KIR2DS4 的缺失变体在重症患者中出现的频率更高。在这项研究中,与重症组相比,轻症组中的和 B 单倍型明显增加(分别为 p = 0.002 和 p = 0.02)。此外,重度组的单倍型 A 的流行率也明显高于轻度组(p = 0.02):这些结果表明,KIR2DS1、KIR2DS 和 B 单倍型可能对 COVID-19 严重程度有保护作用。结果还表明,抑制基因 KIR2DL3 和单倍型 A 是导致 COVID-19 严重程度的危险因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
BMC Immunology
BMC Immunology 医学-免疫学
CiteScore
5.50
自引率
0.00%
发文量
54
审稿时长
1 months
期刊介绍: BMC Immunology is an open access journal publishing original peer-reviewed research articles in molecular, cellular, tissue-level, organismal, functional, and developmental aspects of the immune system as well as clinical studies and animal models of human diseases.
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