Mammalian START-like phosphatidylinositol transfer proteins – Physiological perspectives and roles in cancer biology

IF 3.9 2区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
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引用次数: 0

Abstract

PtdIns and its phosphorylated derivatives, the phosphoinositides, are the biochemical components of a major pathway of intracellular signaling in all eukaryotic cells. These lipids are few in terms of cohort of unique positional isomers, and are quantitatively minor species of the bulk cellular lipidome. Nevertheless, phosphoinositides regulate an impressively diverse set of biological processes. It is from that perspective that perturbations in phosphoinositide-dependent signaling pathways are increasingly being recognized as causal foundations of many human diseases – including cancer. Although phosphatidylinositol transfer proteins (PITPs) are not enzymes, these proteins are physiologically significant regulators of phosphoinositide signaling. As such, PITPs are conserved throughout the eukaryotic kingdom. Their biological importance notwithstanding, PITPs remain understudied. Herein, we review current information regarding PITP biology primarily focusing on how derangements in PITP function disrupt key signaling/developmental pathways and are associated with a growing list of pathologies in mammals.

哺乳动物 START 类磷脂酰肌醇转移蛋白--生理学视角和在癌症生物学中的作用。
PtdIns 及其磷酸化衍生物磷脂是所有真核细胞中细胞内信号传导主要途径的生化成分。这些脂质的独特位置异构体数量很少,在大量细胞脂质组中属于数量较少的种类。然而,磷脂调节的生物过程多种多样,令人印象深刻。正是从这个角度出发,越来越多的人认识到,磷脂酰肌醇依赖性信号通路的扰动是包括癌症在内的许多人类疾病的致病基础。尽管磷脂酰肌醇转移蛋白(PITPs)不是酶,但这些蛋白却是磷脂酰肌醇信号转导的重要生理调节因子。因此,PITPs 在整个真核生物界都是保守的。尽管 PITPs 具有重要的生物学意义,但对它们的研究仍然不足。在本文中,我们回顾了目前有关 PITP 生物学的信息,主要侧重于 PITP 功能失常如何破坏关键的信号/发育途径,并与哺乳动物中越来越多的病症相关联。
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来源期刊
CiteScore
11.00
自引率
2.10%
发文量
109
审稿时长
53 days
期刊介绍: BBA Molecular and Cell Biology of Lipids publishes papers on original research dealing with novel aspects of molecular genetics related to the lipidome, the biosynthesis of lipids, the role of lipids in cells and whole organisms, the regulation of lipid metabolism and function, and lipidomics in all organisms. Manuscripts should significantly advance the understanding of the molecular mechanisms underlying biological processes in which lipids are involved. Papers detailing novel methodology must report significant biochemical, molecular, or functional insight in the area of lipids.
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