Risk of prostate cancer in the proximity of industrial installations: A multicase-control study in Spain (MCC-Spain).

IF 8.2 1区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Science of the Total Environment Pub Date : 2024-10-10 Epub Date: 2024-06-27 DOI:10.1016/j.scitotenv.2024.174347

Javier García-Pérez, Nerea Fernández de Larrea-Baz, Virginia Lope, Alejandro Domínguez-Castillo, Ana Espinosa, Trinidad Dierssen-Sotos, Manuel Contreras-Llanes, María Ángeles Sierra, Gemma Castaño-Vinyals, Adonina Tardón, José J Jiménez-Moleón, Ana Molina-Barceló, Nuria Aragonés, Manolis Kogevinas, Marina Pollán, Beatriz Pérez-Gómez

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引用次数: 0

Abstract

Background: Prostate cancer (PC) is the second most frequent tumor in men worldwide; however, its etiology remains largely unknown, with the exception of age and family history. The wide variability in incidence/mortality across countries suggests a certain role for environmental exposures that has not yet been clarified.

Objective: To evaluate the association between risk of PC (by clinical profile) and residential proximity to pollutant industrial installations (by industrial groups, groups of carcinogens, and specific pollutants released), within the context of a Spanish population-based multicase-control study of incident cancer (MCC-Spain).

Methods: This study included 1186 controls and 234 PC cases, frequency matched by age and province of residence. Distances from participants' residences to the 58 industries located in the study area were calculated and categorized into "near" (considering different limits between ≤1 km and ≤ 3 km) or "far" (>3 km). Odds ratios (ORs) and 95 % confidence intervals (95%CIs) were estimated using mixed and multinomial logistic regression models, adjusted for potential confounders and matching variables.

Results: No excess risk was detected near the overall industries, with ORs ranging from 0.66 (≤2 km) to 1.11 (≤1 km). However, positive associations (OR; 95%CI) were found, by industrial group, near (≤3 km) industries of ceramic (2.54; 1.28-5.07), food/beverage (2.18; 1.32-3.62), and disposal/recycling of animal waste (2.67; 1.12-6.37); and, by specific pollutant, near plants releasing fluorine (4.65; 1.45-14.91 at ≤1.5 km) and chlorine (5.21; 1.56-17.35 at ≤1 km). In contrast, inverse associations were detected near industries releasing ammonia, methane, dioxins+furans, polycyclic aromatic hydrocarbons, trichloroethylene, and vanadium to air.

Conclusions: The results suggest no association between risk of PC and proximity to the overall industrial installations. However, some both positive and inverse associations were detected near certain industrial groups and industries emitting specific pollutants.

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工业设施附近的前列腺癌风险：西班牙多病例对照研究（MCC-Spain）。

背景：前列腺癌（PC）是全球男性第二大高发肿瘤；然而，除年龄和家族史外，其病因在很大程度上仍然不明。各国的发病率/死亡率差异很大，这表明环境暴露在前列腺癌中起着一定的作用，但这种作用尚未得到澄清：目的：在西班牙癌症发病人群多病例对照研究（MCC-Spain）的框架内，评估 PC 风险（按临床特征）与居住地是否靠近污染工业设施（按工业组别、致癌物组别和释放的特定污染物）之间的关联：这项研究包括 1186 例对照组和 234 例 PC 病例，根据年龄和居住省份进行频率匹配。研究人员计算了参与者住所与研究区域内 58 家工业企业之间的距离，并将其分为 "近"（考虑≤1 千米和≤3 千米之间的不同界限）和 "远"（>3 千米）两类。使用混合和多叉逻辑回归模型估算了比值比（ORs）和 95% 置信区间（95%CIs），并对潜在混杂因素和匹配变量进行了调整：整体工业附近未发现超额风险，OR 值从 0.66（≤2 千米）到 1.11（≤1 千米）不等。然而，按行业类别划分，在陶瓷业（2.54；1.28-5.07）、食品/饮料业（2.18；1.32-3.62）和处置/回收业（≤3 公里）附近发现了正相关关系（OR；95%CI）。62）、动物粪便处理/回收（2.67；1.12-6.37）；以及按具体污染物划分，在排放氟（4.65；1.45-14.91，≤1.5 千米）和氯（5.21；1.56-17.35，≤1 千米）的工厂附近。相比之下，在向空气中释放氨、甲烷、二恶英+呋喃、多环芳烃、三氯乙烯和钒的工业附近则发现了反比关系：结论：研究结果表明，PC 风险与靠近所有工业设施之间没有关联。不过，在某些工业组别和排放特定污染物的工业附近发现了一些正相关和反相关关系。

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来源期刊

Science of the Total Environment 环境科学-环境科学

CiteScore

17.60

自引率

10.20%

发文量

8726

审稿时长

2.4 months

期刊介绍： The Science of the Total Environment is an international journal dedicated to scientific research on the environment and its interaction with humanity. It covers a wide range of disciplines and seeks to publish innovative, hypothesis-driven, and impactful research that explores the entire environment, including the atmosphere, lithosphere, hydrosphere, biosphere, and anthroposphere. The journal's updated Aims & Scope emphasizes the importance of interdisciplinary environmental research with broad impact. Priority is given to studies that advance fundamental understanding and explore the interconnectedness of multiple environmental spheres. Field studies are preferred, while laboratory experiments must demonstrate significant methodological advancements or mechanistic insights with direct relevance to the environment.