Serum L C3-II levels in type 2 diabetic patients with impaired renal functions

IF 3.7 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cytokine Pub Date : 2024-06-28 DOI:10.1016/j.cyto.2024.156683

Shahab Ahmed Salıh Gezh , Koksal Deveci , Hakan Sivgin , Figen Guzelgul

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引用次数: 0

Abstract

This study was designed to evaluate serum LC3-II, BCL-2, IL-1β, TGF-β1, and podocin levels in.

type 2 diabetes (T2DM) patients with renal dysfunction.

Materials

176 Turkish subjects were enrolled, of whom 26 were healthy, and 150 had T2DM. Patients.

were classified according to albumin urea ratio: 88 patients had macroalbuminuria, 20.

patients had microalbuminuria, and 42 had normoalbuminuria. T2DM patients were also.

classified into three groups according to proteinuria and eGFR stages.

Results

Increased serum LC3-II levels in patients with T2DM with increased urinary albumin.

extraction and impaired renal functions. There was a strong relationship between serum.

LC3-II levels and serum BCL-2, IL-1β, TGF-β1, and Podocin levels. The efficiency of LC3-

II as a diagnostic biomarker in the differential diagnosis of DM patients with.

macroproteinuria from DM patients with normoproteinuria was 75.4%.

Conclusions

It was thought that increased serum LC3-II levels in T2DM patients with impaired renal.

functions may cause renal podocyte damage. In these patients, serum LC3-II levels can be.

evaluated as a new biomarker to follow the development of renal damage.

Abstract Image

查看原文本刊更多论文

肾功能受损的 2 型糖尿病患者的血清 L C3-II 水平。

本研究旨在评估肾功能不全的 2 型糖尿病（T2DM）患者的血清 LC3-II、BCL-2、IL-1β、TGF-β1 和 podocin 水平：根据白蛋白尿素比值对患者进行分类：88 名患者为大白蛋白尿，20 名患者为小白蛋白尿，42 名患者为正常白蛋白尿。此外，还根据蛋白尿和 eGFR 阶段将 T2DM 患者分为三组：T2DM患者血清LC3-II水平升高与尿白蛋白提取量增加和肾功能受损有密切关系。血清LC3-II水平与血清BCL-2、IL-1β、TGF-β1和Podocin水平之间存在密切关系。LC3- II作为诊断生物标志物在鉴别诊断大蛋白尿DM患者和正常蛋白尿DM患者中的有效率为75.4%：结论：有人认为，肾功能受损的 T2DM 患者血清 LC3-II 水平升高可能导致肾脏荚膜受损。在这些患者中，血清 LC3-II 水平可作为一种新的生物标志物进行评估，以跟踪肾损伤的发展情况。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cytokine 医学-免疫学

CiteScore

7.60

自引率

2.60%

发文量

262

审稿时长

48 days

期刊介绍： The journal Cytokine has an open access mirror journal Cytokine: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. * Devoted exclusively to the study of the molecular biology, genetics, biochemistry, immunology, genome-wide association studies, pathobiology, diagnostic and clinical applications of all known interleukins, hematopoietic factors, growth factors, cytotoxins, interferons, new cytokines, and chemokines, Cytokine provides comprehensive coverage of cytokines and their mechanisms of actions, 12 times a year by publishing original high quality refereed scientific papers from prominent investigators in both the academic and industrial sectors. We will publish 3 major types of manuscripts: 1) Original manuscripts describing research results. 2) Basic and clinical reviews describing cytokine actions and regulation. 3) Short commentaries/perspectives on recently published aspects of cytokines, pathogenesis and clinical results.

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