Research Priorities on the Role of α-Synuclein in Parkinson's Disease Pathogenesis.

IF 7.4 1区医学 Q1 CLINICAL NEUROLOGY

Movement Disorders Pub Date : 2024-06-30 DOI:10.1002/mds.29897

Jacqueline Burré, Robert H Edwards, Glenda Halliday, Anthony E Lang, Hilal A Lashuel, Ronald Melki, Shigeo Murayama, Tiago F Outeiro, Stella M Papa, Leonidas Stefanis, Amanda L Woerman, Dalton James Surmeier, Lorraine V Kalia, Ryosuke Takahashi

{"title":"Research Priorities on the Role of α-Synuclein in Parkinson's Disease Pathogenesis.","authors":"Jacqueline Burré, Robert H Edwards, Glenda Halliday, Anthony E Lang, Hilal A Lashuel, Ronald Melki, Shigeo Murayama, Tiago F Outeiro, Stella M Papa, Leonidas Stefanis, Amanda L Woerman, Dalton James Surmeier, Lorraine V Kalia, Ryosuke Takahashi","doi":"10.1002/mds.29897","DOIUrl":null,"url":null,"abstract":"<p><p>Various forms of Parkinson's disease, including its common sporadic form, are characterized by prominent α-synuclein (αSyn) aggregation in affected brain regions. However, the role of αSyn in the pathogenesis and evolution of the disease remains unclear, despite vast research efforts of more than a quarter century. A better understanding of the role of αSyn, either primary or secondary, is critical for developing disease-modifying therapies. Previous attempts to hone this research have been challenged by experimental limitations, but recent technological advances may facilitate progress. The Scientific Issues Committee of the International Parkinson and Movement Disorder Society (MDS) charged a panel of experts in the field to discuss current scientific priorities and identify research strategies with potential for a breakthrough. © 2024 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.</p>","PeriodicalId":213,"journal":{"name":"Movement Disorders","volume":null,"pages":null},"PeriodicalIF":7.4000,"publicationDate":"2024-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Movement Disorders","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/mds.29897","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Various forms of Parkinson's disease, including its common sporadic form, are characterized by prominent α-synuclein (αSyn) aggregation in affected brain regions. However, the role of αSyn in the pathogenesis and evolution of the disease remains unclear, despite vast research efforts of more than a quarter century. A better understanding of the role of αSyn, either primary or secondary, is critical for developing disease-modifying therapies. Previous attempts to hone this research have been challenged by experimental limitations, but recent technological advances may facilitate progress. The Scientific Issues Committee of the International Parkinson and Movement Disorder Society (MDS) charged a panel of experts in the field to discuss current scientific priorities and identify research strategies with potential for a breakthrough. © 2024 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

查看原文本刊更多论文

α-突触核蛋白在帕金森病发病机制中的作用的研究重点。

各种形式的帕金森病（包括常见的散发性帕金森病）都以受影响脑区突出的α-突触核蛋白（αSyn）聚集为特征。然而，尽管经过超过四分之一世纪的大量研究，αSyn 在该病的发病和演变过程中的作用仍不清楚。更好地了解 αSyn（原发性或继发性）的作用对于开发改变疾病的疗法至关重要。以前为完善这一研究而进行的尝试受到了实验限制的挑战，但最近的技术进步可能会促进研究的进展。国际帕金森病和运动障碍学会（MDS）科学问题委员会责成该领域的一个专家小组讨论当前的科学重点，并确定有可能取得突破的研究策略。作者：© 2024运动障碍》由 Wiley Periodicals LLC 代表国际帕金森和运动障碍学会出版。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Movement Disorders 医学-临床神经学

CiteScore

13.30

自引率

8.10%

发文量

371

审稿时长

12 months

期刊介绍： Movement Disorders publishes a variety of content types including Reviews, Viewpoints, Full Length Articles, Historical Reports, Brief Reports, and Letters. The journal considers original manuscripts on topics related to the diagnosis, therapeutics, pharmacology, biochemistry, physiology, etiology, genetics, and epidemiology of movement disorders. Appropriate topics include Parkinsonism, Chorea, Tremors, Dystonia, Myoclonus, Tics, Tardive Dyskinesia, Spasticity, and Ataxia.