Gas Delivery Relevant to Human Health using Porous Materials

IF 3.7 2区 化学 Q2 CHEMISTRY, MULTIDISCIPLINARY
Ruth M. Mandel, Piyusha S. Lotlikar, Kaitlyn T. Keasler, Elena Y. Chen, Justin J. Wilson, Phillip J. Milner
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Abstract

Gases are essential for various applications relevant to human health, including in medicine, biomedical imaging, and pharmaceutical synthesis. However, gases are significantly more challenging to safely handle than liquids and solids. Herein, we review the use of porous materials, such as metal-organic frameworks (MOFs), zeolites, and silicas, to adsorb medicinally relevant gases and facilitate their handling as solids. Specific topics include the use of MOFs and zeolites to deliver H2S for therapeutic applications, 129Xe for magnetic resonance imaging, O2 for the treatment of cancer and hypoxia, and various gases for use in organic synthesis. This Perspective aims to bring together the organic, inorganic, medicinal, and materials chemistry communities to inspire the design of next-generation porous materials for the storage and delivery of medicinally relevant gases.

Abstract Image

Abstract Image

利用多孔材料输送与人体健康相关的气体。
气体对于与人类健康相关的各种应用至关重要,包括医学、生物医学成像和药物合成。然而,与液体和固体相比,气体的安全处理更具挑战性。在此,我们将综述多孔材料(如金属有机框架 (MOF)、沸石和硅胶)在吸附药用气体方面的应用,以及如何将其作为固体进行处理。具体主题包括利用 MOFs 和沸石输送治疗用 H2S、磁共振成像用 129Xe、治疗癌症和缺氧的 O2 以及用于有机合成的各种气体。本视角旨在汇聚有机、无机、药物和材料化学界的力量,启发设计下一代多孔材料,用于储存和输送药物相关气体。
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来源期刊
Chemistry - A European Journal
Chemistry - A European Journal 化学-化学综合
CiteScore
7.90
自引率
4.70%
发文量
1808
审稿时长
1.8 months
期刊介绍: Chemistry—A European Journal is a truly international journal with top quality contributions (2018 ISI Impact Factor: 5.16). It publishes a wide range of outstanding Reviews, Minireviews, Concepts, Full Papers, and Communications from all areas of chemistry and related fields. Based in Europe Chemistry—A European Journal provides an excellent platform for increasing the visibility of European chemistry as well as for featuring the best research from authors from around the world. All manuscripts are peer-reviewed, and electronic processing ensures accurate reproduction of text and data, plus short publication times. The Concepts section provides nonspecialist readers with a useful conceptual guide to unfamiliar areas and experts with new angles on familiar problems. Chemistry—A European Journal is published on behalf of ChemPubSoc Europe, a group of 16 national chemical societies from within Europe, and supported by the Asian Chemical Editorial Societies. The ChemPubSoc Europe family comprises: Angewandte Chemie, Chemistry—A European Journal, European Journal of Organic Chemistry, European Journal of Inorganic Chemistry, ChemPhysChem, ChemBioChem, ChemMedChem, ChemCatChem, ChemSusChem, ChemPlusChem, ChemElectroChem, and ChemistryOpen.
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