Associations of short-term changes in obesity indices with all-cause mortality and cardiovascular disease

IF 4.2 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Obesity Pub Date : 2024-06-24 DOI:10.1002/oby.24062
Lyu Wang, Yun-Yang Deng, Tsung Yu, Xiang-Qian Lao, Martin C. S. Wong
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Abstract

Objective

This study aimed to investigate how short-term changes (1-, 3-, and 5-year) in obesity measures affect mortality and cardiovascular disease (CVD) risk.

Methods

We analyzed longitudinal data from the MJ Health Centre (n = 43,304 for the 1-year study; 24,295 for the 3-year study; 16,138 for the 5-year study) with median follow-up periods of 15.8, 13.9, and 12.3 years, respectively. Associations of short-term obesity indices changes with mortality and Framingham Risk Score changes were explored using time-dependent coefficient Cox regression models, restricted cubic splines, and multivariable linear regression models.

Results

All-cause mortality was negatively associated with short-term weight and BMI changes, with greater reductions causing poorer outcomes. Compared with stable groups, short-term reduced weight and BMI were associated with greater risks of all-cause mortality and CVD-specific mortality (5-year study only). Also, either 1- and 3-year reduced or 3-year increased waist circumference and waist to height ratio were related to higher all-cause and CVD deaths than stable groups, respectively. Nonlinear relationships indicated lower cutoff values for short-term changes in obesity indices in predicting all-cause mortality. Decreased obesity indices significantly improved CVD profiles.

Conclusions

Short-term changes in obesity indices show complex mortality risks, urging personalized approaches beyond a simple weight loss focus.

Abstract Image

肥胖指数的短期变化与全因死亡率和心血管疾病的关系。
研究目的本研究旨在探讨肥胖指标的短期变化(1年、3年和5年)如何影响死亡率和心血管疾病(CVD)风险:我们分析了来自 MJ 健康中心的纵向数据(1 年研究 n = 43,304 人;3 年研究 n = 24,295 人;5 年研究 n = 16,138 人),中位随访期分别为 15.8 年、13.9 年和 12.3 年。研究人员使用时间依赖系数考克斯回归模型、限制性三次样条和多变量线性回归模型探讨了短期肥胖指数变化与死亡率和弗雷明汉风险评分变化之间的关系:结果:全因死亡率与体重和体重指数的短期变化呈负相关,降低幅度越大,结果越差。与稳定组相比,短期体重和体重指数下降与更高的全因死亡率和心血管疾病特异性死亡率风险相关(仅为 5 年研究)。此外,与稳定组相比,腰围和腰围身高比在 1 年和 3 年减少或 3 年增加分别与更高的全因死亡率和心血管疾病死亡率有关。非线性关系表明,肥胖指数的短期变化在预测全因死亡率方面的临界值较低。肥胖指数的降低能显著改善心血管疾病的情况:结论:肥胖指数的短期变化显示了复杂的死亡风险,因此需要采取个性化的方法,而不仅仅是单纯的减肥。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Obesity
Obesity 医学-内分泌学与代谢
CiteScore
11.70
自引率
1.40%
发文量
261
审稿时长
2-4 weeks
期刊介绍: Obesity is the official journal of The Obesity Society and is the premier source of information for increasing knowledge, fostering translational research from basic to population science, and promoting better treatment for people with obesity. Obesity publishes important peer-reviewed research and cutting-edge reviews, commentaries, and public health and medical developments.
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