Advances in understanding the roles of actin scaffolding and membrane trafficking in dendrite development.

IF 6.6 2区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Journal of Genetics and Genomics Pub Date : 2024-11-01 Epub Date: 2024-06-24 DOI:10.1016/j.jgg.2024.06.010
Wanting Wang, Menglong Rui
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引用次数: 0

Abstract

Dendritic morphology is typically highly branched, and the branching and synaptic abundance of dendrites can enhance the receptive range of neurons and the diversity of information received, thus providing the basis for information processing in the nervous system. Once dendritic development is aberrantly compromised or damaged, it may lead to abnormal connectivity of the neural network, affecting the function and stability of the nervous system and ultimately triggering a series of neurological disorders. Research on the regulation of dendritic developmental processes has flourished, and much progress is now being made in its regulatory mechanisms. Noteworthily, dendrites are characterized by an extremely complex dendritic arborization that cannot be attributed to individual protein functions alone, requiring a systematic analysis of the intrinsic and extrinsic signals and the coordinated roles among them. Actin cytoskeleton organization and membrane vesicle trafficking are required during dendrite development, with actin providing tracks for vesicles and vesicle trafficking in turn providing material for actin assembly. In this review, we focus on these two basic biological processes and discuss the molecular mechanisms and their synergistic effects underlying the morphogenesis of neuronal dendrites. We also offer insights and discuss strategies for the potential preventive and therapeutic treatment of neuropsychiatric disorders.

进一步了解肌动蛋白支架和膜贩运在树突发育中的作用。
树突形态通常具有高度分枝性,树突的分枝性和突触的丰富性可以增强神经元的感受范围和接收信息的多样性,从而为神经系统的信息处理提供基础。一旦树突发育受到异常损害或破坏,就可能导致神经网络的连接异常,影响神经系统的功能和稳定性,最终引发一系列神经系统疾病。对树突发育过程调控的研究蓬勃发展,目前在其调控机制方面取得了很大进展。值得注意的是,树突的特点是树突轴化极其复杂,不能仅归因于单个蛋白质的功能,需要系统分析内在和外在信号以及它们之间的协调作用。树突发育过程中需要肌动蛋白细胞骨架组织和膜囊泡贩运,肌动蛋白为囊泡提供轨道,囊泡贩运反过来又为肌动蛋白组装提供材料。在这篇综述中,我们将重点关注这两个基本的生物过程,并讨论神经元树突形态发生的分子机制及其协同效应。我们还将深入探讨神经精神疾病的潜在预防和治疗策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Genetics and Genomics
Journal of Genetics and Genomics 生物-生化与分子生物学
CiteScore
8.20
自引率
3.40%
发文量
4756
审稿时长
14 days
期刊介绍: The Journal of Genetics and Genomics (JGG, formerly known as Acta Genetica Sinica ) is an international journal publishing peer-reviewed articles of novel and significant discoveries in the fields of genetics and genomics. Topics of particular interest include but are not limited to molecular genetics, developmental genetics, cytogenetics, epigenetics, medical genetics, population and evolutionary genetics, genomics and functional genomics as well as bioinformatics and computational biology.
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