Yajing Qiu, Ermei Xie, Haipeng Xu, Hongcheng Cheng, Guideng Li
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引用次数: 0
Abstract
One-carbon metabolism (1CM), comprising folate metabolism and methionine metabolism, serves as an important mechanism for cellular energy provision and the production of vital signaling molecules, including single-carbon moieties. Its regulation is instrumental in sustaining the proliferation of cancer cells and facilitating metastasis; in addition, recent research has shed light on its impact on the efficacy of T cell-mediated immunotherapy. In this review, we consolidate current insights into how 1CM affects T cell activation, differentiation, and functionality. Furthermore, we delve into the strategies for modulating 1CM in both T cells and tumor cells to enhance the efficacy of adoptively transferred T cells, overcome metabolic challenges in the tumor microenvironment (TME), and maximize the benefits of T cell-mediated immunotherapy.
单碳代谢（1CM）包括叶酸代谢和蛋氨酸代谢，是细胞提供能量和产生重要信号分子（包括单碳分子）的重要机制。它的调节在维持癌细胞增殖和促进癌细胞转移方面起着重要作用；此外，最近的研究还揭示了它对 T 细胞介导的免疫疗法疗效的影响。在本综述中，我们整合了目前对 1CM 如何影响 T 细胞活化、分化和功能的见解。此外，我们还深入探讨了调节 T 细胞和肿瘤细胞中 1CM 的策略，以提高被收养转移 T 细胞的疗效，克服肿瘤微环境 (TME) 中的代谢挑战，并最大限度地提高 T 细胞介导的免疫疗法的效益。
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Trends in Endocrinology and Metabolism (TEM) stands as a premier Reviews journal in the realms of metabolism and endocrinology. Our commitment is reflected in the publication of refined, concise, and highly impactful articles that delve into cutting-edge topics, encompassing basic, translational, and clinical aspects. From state-of-the-art treatments for endocrine diseases to groundbreaking developments in molecular biology, TEM provides comprehensive coverage.
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