Out of the dark: the emerging roles of lncRNAs in pain.

IF 13.6 2区 生物学 Q1 GENETICS & HEREDITY
Trends in Genetics Pub Date : 2024-08-01 Epub Date: 2024-06-25 DOI:10.1016/j.tig.2024.04.009
Abdella M Habib, James J Cox, Andrei L Okorokov
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引用次数: 0

Abstract

The dark genome, the nonprotein-coding part of the genome, is replete with long noncoding RNAs (lncRNAs). These functionally versatile transcripts, with specific temporal and spatial expression patterns, are critical gene regulators that play essential roles in health and disease. In recent years, FAAH-OUT was identified as the first lncRNA associated with an inherited human pain insensitivity disorder. Several other lncRNAs have also been studied for their contribution to chronic pain and genome-wide association studies are frequently identifying single nucleotide polymorphisms that map to lncRNAs. For a long time overlooked, lncRNAs are coming out of the dark and into the light as major players in human pain pathways and as potential targets for new RNA-based analgesic medicines.

走出黑暗:lncRNA 在疼痛中的新作用。
黑暗基因组(基因组的非蛋白编码部分)充满了长非编码 RNA(lncRNA)。这些功能多变的转录本具有特定的时间和空间表达模式,是关键的基因调控因子,在健康和疾病中发挥着至关重要的作用。近年来,FAAH-OUT 被确定为第一个与遗传性人类疼痛不敏感症相关的 lncRNA。人们还研究了其他一些 lncRNA 对慢性疼痛的影响,全基因组关联研究也经常发现与 lncRNA 有关的单核苷酸多态性。长期被忽视的 lncRNA 正在走出黑暗,走向光明,成为人类疼痛通路中的主要参与者,以及基于 RNA 的新型镇痛药物的潜在靶点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Trends in Genetics
Trends in Genetics 生物-遗传学
CiteScore
20.90
自引率
0.90%
发文量
160
审稿时长
6-12 weeks
期刊介绍: Launched in 1985, Trends in Genetics swiftly established itself as a "must-read" for geneticists, offering concise, accessible articles covering a spectrum of topics from developmental biology to evolution. This reputation endures, making TiG a cherished resource in the genetic research community. While evolving with the field, the journal now embraces new areas like genomics, epigenetics, and computational genetics, alongside its continued coverage of traditional subjects such as transcriptional regulation, population genetics, and chromosome biology. Despite expanding its scope, the core objective of TiG remains steadfast: to furnish researchers and students with high-quality, innovative reviews, commentaries, and discussions, fostering an appreciation for advances in genetic research. Each issue of TiG presents lively and up-to-date Reviews and Opinions, alongside shorter articles like Science & Society and Spotlight pieces. Invited from leading researchers, Reviews objectively chronicle recent developments, Opinions provide a forum for debate and hypothesis, and shorter articles explore the intersection of genetics with science and policy, as well as emerging ideas in the field. All articles undergo rigorous peer-review.
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