Vascular Ehlers-Danlos syndrome and pregnancy: A systematic review

IF 5.4 3区材料科学 Q2 CHEMISTRY, PHYSICAL

ACS Applied Energy Materials Pub Date : 2024-06-26 DOI:10.1111/1471-0528.17893

Théo Haem, Betty Benson, Amandine Dernoncourt, Jean Gondry, Jean Schmidt, Arthur Foulon

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Abstract

Background

Vascular Ehlers-Danlos syndrome (vEDS) is a hereditary connective tissue disorder associated with an elevated risk of vascular, uterine and digestive complications. Managing pregnancy in this context can be a challenge.

Objectives

To systematically review the literature data on the complications in pregnancy associated with vEDS.

Search strategy

We searched the Pubmed Medline and Embase databases for articles using the following terms “vascular Ehlers-Danlos syndrome” or “vEDS” AND “pregnancy”.

Selection criteria

Women with vEDS.

Data collection and analysis

We searched the PubMed® MEDLINE® database for publications evaluating obstetric outcomes in women with vEDS.

Main results

A total of 121 publications were screened, with six (accounting for 412 pregnancies) included in our review. Of the women included in this sample, 30% were infertile. The miscarriage rate was 13.8% (57/412) and 8.8% of the live births were premature. Obstetric anal sphincter injuries occurred in 11.3% (23/203) of the deliveries. The maternal mortality rate per pregnancy was 5.7%.

Conclusions

Women with vEDS present an elevated risk of uterine rupture, vascular events, digestive events and death during pregnancy. Women appear to be most at risk during the peripartum period; to avoid expulsive efforts, a caesarean section should be scheduled at 37 weeks of gestation.

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血管性埃勒斯-丹洛斯综合征与妊娠：系统综述。

背景：血管性埃勒斯-丹洛斯综合征（vEDS血管性埃勒斯-丹洛斯综合征（vEDS）是一种遗传性结缔组织疾病，与血管、子宫和消化系统并发症的高风险有关。在这种情况下管理妊娠是一项挑战：系统回顾与 vEDS 相关的妊娠并发症的文献数据：我们在 Pubmed Medline 和 Embase 数据库中以 "血管性 Ehlers-Danlos 综合征 "或 "vEDS "和 "妊娠 "为关键词检索文章：数据收集与分析：我们在PubMed® MEDLINE®数据库中检索了评估vEDS女性产科结果的出版物：主要结果：共筛选出 121 篇出版物，其中 6 篇（涉及 412 例妊娠）被纳入我们的综述。在这些样本中，30%的女性未育。流产率为13.8%（57/412），8.8%的活产为早产。产科肛门括约肌损伤发生率为 11.3%（23/203）。每次妊娠的产妇死亡率为 5.7%：结论：患有vEDS的妇女在怀孕期间发生子宫破裂、血管事件、消化系统事件和死亡的风险较高。妇女在围产期面临的风险似乎最大；为避免用力挤压，应在妊娠 37 周时安排剖腹产。

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来源期刊

ACS Applied Energy Materials Materials Science-Materials Chemistry

CiteScore

10.30

自引率

6.20%

发文量

1368

期刊介绍： ACS Applied Energy Materials is an interdisciplinary journal publishing original research covering all aspects of materials, engineering, chemistry, physics and biology relevant to energy conversion and storage. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important energy applications.