Incidence distributions, risk factors and trends of vaginal cancer: A global population-based study

IF 5.4 3区材料科学 Q2 CHEMISTRY, PHYSICAL

ACS Applied Energy Materials Pub Date : 2024-06-25 DOI:10.1111/1471-0528.17887

Junjie Huang, Sze Chai Chan, Wing Sze Pang, Fung Yu Mak, Yat Ching Fung, Veeleah Lok, Lin Zhang, Xu Lin, Don Eliseo Lucero-Prisno III, Wanghong Xu, Zhi-Jie Zheng, Edmar Elcarte, Mellissa Withers, Martin C. S. Wong, the NCD Global Health Research Group, Association of Pacific Rim Universities (APRU)

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引用次数: 0

Abstract

Objective

This study aimed to investigate the incidence, risk factors and trends for vaginal cancer.

Design

Retrospective observational design.

Setting

Data were collected from multiple sources, including the Global Cancer Observatory, Cancer Incidence in Five Continents Plus, Global Burden of Disease, World Bank and the United Nations.

Population

Individuals diagnosed with vaginal cancer.

Methods

The study collected data on vaginal cancer from the specified sources. The age-standardised rate (ASR) of vaginal cancer was calculated for different regions and age groups. Multivariable and univariable linear regression analyses were performed to examine the associations between risk factors and the incidence of vaginal cancer. Trend analysis was conducted using joinpoint regression analysis, and the average annual percentage change (AAPC) was calculated to quantify the temporal trend.

Main Outcome Measures

The main outcome measures of the study were the incidence of vaginal cancer, risk factors associated with the disease and the trend of its incidence over time.

Results

There were 17 908 newly reported cases of vaginal cancer (ASR = 0.36, 95% CI 0.30–0.44) in 2020, with the highest ASRs reported in South–Central Asia and Southern Africa. Risk factors associated with a higher incidence of vaginal cancer included a higher prevalence of unsafe sex and human immunodeficiency virus (HIV) infection. The temporal trend showed an overall rising incidence globally, with Iceland (AAPC = 29.56, 95% CI 12.12–49.71), Chile (AAPC = 22.83, 95% CI 13.20–33.27), Bahrain (AAPC = 22.05, 95% CI 10.83–34.40) and the UK (AAPC = 1.40, 95% CI 0.41–2.39) demonstrating the most significant rising trends.

Conclusions

The significant regional disparities and risk factors associated with vaginal cancer underscore the necessity for targeted interventions and education, particularly in regions with a lower human development index (HDI) and a higher prevalence of human papillomavirus (HPV) infection. The increasing incidence trend emphasises the need for enhanced HPV vaccination rates to prevent the development of vaginal cancer.

Abstract Image

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阴道癌的发病率分布、风险因素和趋势：全球人口研究。

目的：本研究旨在调查阴道癌的发病率、风险因素和发展趋势：本研究旨在调查阴道癌的发病率、风险因素和发展趋势：设计：回顾性观察设计：数据来自多个来源，包括全球癌症观察站、五大洲癌症发病率+、全球疾病负担、世界银行和联合国：方法：收集阴道癌数据：研究从指定来源收集阴道癌数据。计算了不同地区和年龄组的阴道癌年龄标准化比率（ASR）。对风险因素与阴道癌发病率之间的关系进行了多变量和单变量线性回归分析。使用连接点回归分析法进行趋势分析，并计算年平均百分比变化（AAPC），以量化时间趋势：研究的主要结果是阴道癌的发病率、与该疾病相关的风险因素以及发病率的时间趋势：2020年新报告的阴道癌病例为17 908例（ASR=0.36，95% CI 0.30-0.44），中南亚和南部非洲的ASR最高。与阴道癌发病率较高相关的风险因素包括不安全性行为和人体免疫缺陷病毒（HIV）感染率较高。时间趋势显示，全球发病率总体呈上升趋势，其中冰岛（AAPC = 29.56，95% CI 12.12-49.71）、智利（AAPC = 22.83，95% CI 13.20-33.27）、巴林（AAPC = 22.05，95% CI 10.83-34.40）和英国（AAPC = 1.40，95% CI 0.41-2.39）的上升趋势最为显著：与阴道癌相关的重大地区差异和风险因素强调了有针对性干预和教育的必要性，尤其是在人类发展指数（HDI）较低和人类乳头瘤病毒（HPV）感染率较高的地区。发病率上升的趋势突出表明，有必要提高人类乳头瘤病毒疫苗接种率，以预防阴道癌的发生。

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来源期刊

ACS Applied Energy Materials Materials Science-Materials Chemistry

CiteScore

10.30

自引率

6.20%

发文量

1368

期刊介绍： ACS Applied Energy Materials is an interdisciplinary journal publishing original research covering all aspects of materials, engineering, chemistry, physics and biology relevant to energy conversion and storage. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important energy applications.