{"title":"Subpopulations of neurons in the perirhinal cortex enable both modality-specific and modality-invariant recognition of objects.","authors":"Heung-Yeol Lim, Inah Lee","doi":"10.1371/journal.pbio.3002713","DOIUrl":null,"url":null,"abstract":"<p><p>The perirhinal cortex (PER) supports multimodal object recognition, but how multimodal information of objects is integrated within the PER remains unknown. Here, we recorded single units within the PER while rats performed a PER-dependent multimodal object-recognition task. In this task, audiovisual cues were presented simultaneously (multimodally) or separately (unimodally). We identified 2 types of object-selective neurons in the PER: crossmodal cells, showing constant firing patterns for an object irrespective of its modality, and unimodal cells, showing a preference for a specific modality. Unimodal cells further dissociated unimodal and multimodal versions of the object by modulating their firing rates according to the modality condition. A population-decoding analysis confirmed that the PER could perform both modality-invariant and modality-specific object decoding-the former for recognizing an object as the same in various conditions and the latter for remembering modality-specific experiences of the same object.</p>","PeriodicalId":49001,"journal":{"name":"PLoS Biology","volume":null,"pages":null},"PeriodicalIF":9.8000,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11233021/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"PLoS Biology","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1371/journal.pbio.3002713","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/6/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"Agricultural and Biological Sciences","Score":null,"Total":0}
引用次数: 0
Abstract
The perirhinal cortex (PER) supports multimodal object recognition, but how multimodal information of objects is integrated within the PER remains unknown. Here, we recorded single units within the PER while rats performed a PER-dependent multimodal object-recognition task. In this task, audiovisual cues were presented simultaneously (multimodally) or separately (unimodally). We identified 2 types of object-selective neurons in the PER: crossmodal cells, showing constant firing patterns for an object irrespective of its modality, and unimodal cells, showing a preference for a specific modality. Unimodal cells further dissociated unimodal and multimodal versions of the object by modulating their firing rates according to the modality condition. A population-decoding analysis confirmed that the PER could perform both modality-invariant and modality-specific object decoding-the former for recognizing an object as the same in various conditions and the latter for remembering modality-specific experiences of the same object.
虹膜周围皮层(PER)支持多模态物体识别,但物体的多模态信息是如何在 PER 中整合的仍是未知数。在这里,我们记录了大鼠执行一项依赖于 PER 的多模态物体识别任务时 PER 内的单个单元。在这项任务中,视听线索同时(多模态)或分别(单模态)呈现。我们在 PER 中发现了两种类型的对象选择性神经元:跨模态细胞和单模态细胞,前者表现出对对象的恒定发射模式,而与对象的模态无关;后者则表现出对特定模态的偏好。单模态细胞根据模态条件调节其发射率,从而进一步区分物体的单模态和多模态版本。群体解码分析证实,PER可以进行模式不变和特定模式的对象解码--前者用于识别在不同条件下相同的对象,后者用于记忆同一对象的特定模式经验。
期刊介绍:
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