{"title":"[Effect of <i>TP53</i> Allelic State on Clinical Performance and Prognosis of Patients with Myelodysplastic Syndrome].","authors":"Kai Shen, De-Yuan Hu, Su-Ning Chen","doi":"10.19746/j.cnki.issn.1009-2137.2024.03.024","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To investigate the clinical significance of <i>TP53</i> allelic state in patients with myelodysplastic syndromes (MDS).</p><p><strong>Methods: </strong>The clinical data of 858 MDS patients who underwent second-generation sequencing (NGS) testing in the First Affiliated Hospital of Soochow University from January 2019 to December 2021 were retrospectively analyzed.</p><p><strong>Results: </strong>The median age of the patients was 52 years old, and median follow-up time was 23.8 (0.4-109.6) months. Four hundred and one patients (46.7%) had at least one chromosomal abnormality, including 106 complex karyotypes and 78 monosomal karyotypes. A total of 103 cases of <i>TP53</i> mutations were identified, with a mutation rate of 12%. Compared with <i>TP53</i> wild-type, various types of chromosomal abnormalities were significantly more common in patients with <i>TP53</i> mutations (all <i>P</i> < 0.001). Patients with <i>TP53</i> mutations had lower hemoglobin levels, lower platelet counts and higher percentage of bone marrow primitive cell compared with <i>TP53</i> wild type (all <i>P</i> < 0.05), and significantly shorter overall survival (OS). Among 97 evaluable patients, 33 cases (34%) were mono-allelic <i>TP53</i> mutation, while 64 cases were bi-allelic <i>TP53</i> mutation. Patients in bi-allelic <i>TP53</i> mutation subgroup had a higher proportion of chromosomal abnormalities and a lower number of co-mutations compared with mono-allelic <i>TP53</i> mutation. The median OS was 33.6 months in patients with mono-allelic state and only 11.4 months in patients with bi-allelic state (<i>HR</i>=2.138, 95%<i>CI</i> : 1.053-4.343, <i>P</i> >0.05). Median OS was not reached in <i>TP53</i> wild-type patients, and there was a significant difference in OS among <i>TP53</i> wild-type, mono-allelic and bi-allelic <i>TP53</i> mutation patients (<i>P</i> < 0.001). Multivariable Cox regression analysis showed that bi-allelic <i>TP53</i> was an independent predictor of poor outcomes (<i>HR</i>=2.808, 95%<i>CI</i> : 1.487-5.003, <i>P</i> =0.001), while mono-allelic <i>TP53</i> mutation and wild-type <i>TP53</i> were not.</p><p><strong>Conclusion: </strong>Patients with <i>TP53</i> mutations have a poor prognosis, and bi-allelic <i>TP53</i> mutations have a worse prognosis compared with mono-allelic <i>TP53</i> mutations and independently affect the prognosis of MDS patients.</p>","PeriodicalId":35777,"journal":{"name":"中国实验血液学杂志","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"中国实验血液学杂志","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.19746/j.cnki.issn.1009-2137.2024.03.024","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
Objective: To investigate the clinical significance of TP53 allelic state in patients with myelodysplastic syndromes (MDS).
Methods: The clinical data of 858 MDS patients who underwent second-generation sequencing (NGS) testing in the First Affiliated Hospital of Soochow University from January 2019 to December 2021 were retrospectively analyzed.
Results: The median age of the patients was 52 years old, and median follow-up time was 23.8 (0.4-109.6) months. Four hundred and one patients (46.7%) had at least one chromosomal abnormality, including 106 complex karyotypes and 78 monosomal karyotypes. A total of 103 cases of TP53 mutations were identified, with a mutation rate of 12%. Compared with TP53 wild-type, various types of chromosomal abnormalities were significantly more common in patients with TP53 mutations (all P < 0.001). Patients with TP53 mutations had lower hemoglobin levels, lower platelet counts and higher percentage of bone marrow primitive cell compared with TP53 wild type (all P < 0.05), and significantly shorter overall survival (OS). Among 97 evaluable patients, 33 cases (34%) were mono-allelic TP53 mutation, while 64 cases were bi-allelic TP53 mutation. Patients in bi-allelic TP53 mutation subgroup had a higher proportion of chromosomal abnormalities and a lower number of co-mutations compared with mono-allelic TP53 mutation. The median OS was 33.6 months in patients with mono-allelic state and only 11.4 months in patients with bi-allelic state (HR=2.138, 95%CI : 1.053-4.343, P >0.05). Median OS was not reached in TP53 wild-type patients, and there was a significant difference in OS among TP53 wild-type, mono-allelic and bi-allelic TP53 mutation patients (P < 0.001). Multivariable Cox regression analysis showed that bi-allelic TP53 was an independent predictor of poor outcomes (HR=2.808, 95%CI : 1.487-5.003, P =0.001), while mono-allelic TP53 mutation and wild-type TP53 were not.
Conclusion: Patients with TP53 mutations have a poor prognosis, and bi-allelic TP53 mutations have a worse prognosis compared with mono-allelic TP53 mutations and independently affect the prognosis of MDS patients.