[XVI Post-ECTRIMS Meeting: review of the new developments presented at the 2023 ECTRIMS Congress (I)].

IF 0.8 4区 医学 Q4 CLINICAL NEUROLOGY
O Fernández, X Montalbán, E Agüera, Y Aladro, A Alonso, R Arroyo, L Brieva, C Calles, L Costa-Frossard, S Eichau, J M García-Domínguez, M A Hernández, L Landete, M Llaneza, S Llufriu, J E Meca-Lallana, V Meca-Lallana, E Moral, J M Prieto, Ll Ramió-Torrentà, N Téllez, L Romero-Pinel, A Vilaseca, A Rodríguez-Antigüedad
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Abstract

The XVI Post-ECTRIMS meeting took place in Seville on 20 and 21 October 2023. This meeting was attended by neurologists specialising in multiple sclerosis (MS) from Spain, who shared a summary of the most interesting innovations at the ECTRIMS congress, which had taken place in Milan the previous week. The aim of this article is to summarise new developments related to the pathogenesis, diagnosis and prognosis of MS. The contributions of innate immunity and central nervous system resident cells, including macrophages and microglia in MS pathophysiology and as therapeutic targets were discussed. Compartmentalised intrathecal inflammation was recognised as central to understanding the progression of MS, and the relationship between inflammatory infiltrates and disease progression was highlighted. Perspectives in demyelinating pathologies were reviewed, focusing on neuromyelitis optica and myelin oligodendrocyte glycoprotein antibody-associated disease, highlighting their pathophysiological and diagnostic differences compared to MS. Advances in neuroimaging were also discussed, and especially the analysis of active chronic lesions, such as paramagnetic rim lesions. In the absence of clinical improvements in trials of remyelinating treatments, methodological strategies to optimise the design of future studies were proposed. Breakthroughs in detecting the prodromal phase of MS, the use of biomarkers in body fluids to assess activity, progression and treatment response, and research on progression independent of flares were addressed. The need to define criteria for radiologically isolated syndrome and to clarify the concept was also discussed.

[第十六届欧洲热带金枪鱼研究中心会后会议:2023 年欧洲热带金枪鱼研究中心大会新进展回顾(I)]。
2023 年 10 月 20-21 日,第十六届欧洲多发性硬化大会后会议在塞维利亚举行。来自西班牙的多发性硬化症(MS)神经病学专家参加了此次会议,并分享了上周在米兰举行的欧洲多发性硬化症大会上最令人关注的创新成果。本文旨在总结多发性硬化症发病机制、诊断和预后方面的新进展。文章讨论了先天性免疫和中枢神经系统驻留细胞(包括巨噬细胞和小胶质细胞)在多发性硬化症病理生理学中的作用以及作为治疗靶点的作用。会议认为,椎管内炎症是了解多发性硬化症进展的核心,并强调了炎症浸润与疾病进展之间的关系。会议回顾了脱髓鞘病理学的发展前景,重点讨论了神经性脊髓炎和髓鞘少突胶质细胞糖蛋白抗体相关疾病,强调了它们与多发性硬化症在病理生理学和诊断上的差异。会议还讨论了神经影像学的进展,尤其是对顺磁边缘病变等活动性慢性病灶的分析。由于再髓鞘化治疗试验的临床效果没有改善,会议提出了优化未来研究设计的方法策略。会议讨论了在检测多发性硬化症前驱期、使用体液中的生物标志物评估活动、进展和治疗反应以及独立于发作的进展研究方面取得的突破。会议还讨论了界定放射学孤立综合征标准和澄清这一概念的必要性。
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来源期刊
Revista de neurologia
Revista de neurologia 医学-临床神经学
CiteScore
2.50
自引率
8.30%
发文量
117
审稿时长
3-8 weeks
期刊介绍: Revista de Neurología fomenta y difunde el conocimiento generado en lengua española sobre neurociencia, tanto clínica como experimental.
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