Reduced Cochlear MRI Signal and Hearing Outcomes in Conservatively Managed Vestibular Schwannoma Patients.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-08-01 Epub Date: 2024-06-26 DOI:10.1097/MAO.0000000000004239

Arthur Jones, Lydia Saputra, Timothy Matthews

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引用次数: 0

Abstract

Objective: This study aimed to determine if hypointense cochlear magnetic resonance imaging (MRI) constructive interference in steady-state (CISS) signal correlates with hearing outcomes in conservatively managed vestibular schwannoma (VS) patients.

Study design: Retrospective review of 657 cases from 1992 to 2020.

Setting: Tertiary academic referral center.

Patients: A retrospective review was performed to identify conservatively managed VS patients with appropriate baseline MRI, audiology, and at least 12-month audiological follow-up. Patients were excluded if they progressed to surgery or radiotherapy in less than 12 months, bilateral tumors, or surgery on the contralateral ear.

Intervention: Conservatively managed patients with CISS imaging studies and audiology testing.

Main outcome measures: Primary outcome measure change in pure-tone average (PTA) and word recognition score (WRS). Secondary outcome measures tumor size, presence of lateral fluid cap, or cystic changes.

Results: A total of 92 individuals (47% male, 58 ± 11.6 yr) met the inclusion criteria, with 36 (39%) of patients demonstrating abnormal cochlear CISS signal. At baseline, abnormal cochlear CISS signal was associated with higher intracanalicular (IC) length (7.9 versus 6.6 mm, p = 0.0177) and lower WRS (55.7 versus 78.8 dBHL, p = 0.0054). During follow-up, individuals with abnormal cochlear CISS signal had significantly higher PTA (62.4 versus 46.4 dBHL, p = 0.0010). After adjusting for baseline covariates, abnormal cochlear CISS signal was consistently associated with a greater increase in PTA of 8.3 dBHL (95% confidence interval, 2.9-13.7; p = 0.0032) from baseline when compared with the normal group.

Conclusions: Abnormal cochlear signal on MRI CISS sequences is associated with poorer hearing outcomes in conservatively managed VS patients.

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保守治疗的前庭许旺瘤患者耳蜗 MRI 信号减少与听力结果

研究目的本研究旨在确定低密度耳蜗磁共振成像（MRI）稳态建设性干扰（CISS）信号是否与保守治疗的前庭分裂瘤（VS）患者的听力结果相关：背景：三级学术转诊中心：研究地点：三级学术转诊中心：进行回顾性研究，以确定保守治疗的 VS 患者，这些患者具有适当的基线 MRI、听力检查和至少 12 个月的听力随访。如果患者在不到 12 个月的时间内进展为手术或放疗、双侧肿瘤或对侧耳手术，则将其排除在外：主要结果测量指标：主要结果测量：纯音平均值（PTA）和单词识别评分（WRS）的变化。次要结果测量肿瘤大小、是否存在侧液帽或囊性改变：共有 92 人（47% 为男性，58 ± 11.6 岁）符合纳入标准，其中 36 人（39%）显示出耳蜗 CISS 信号异常。基线时，耳蜗 CISS 信号异常与较高的耳蜗内 (IC) 长度（7.9 毫米对 6.6 毫米，p = 0.0177）和较低的 WRS（55.7 分贝HL 对 78.8 分贝HL，p = 0.0054）有关。在随访期间，耳蜗 CISS 信号异常者的 PTA 明显更高（62.4 对 46.4 dBHL，p = 0.0010）。调整基线协变量后，与正常组相比，异常耳蜗 CISS 信号始终与 PTA 从基线增加 8.3 dBHL（95% 置信区间，2.9-13.7；p = 0.0032）相关：结论：MRI CISS 序列上异常的耳蜗信号与保守治疗的 VS 患者较差的听力预后有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.