Association Between EEG Power During Sleep and Attention Levels in Patients with Major Depressive Disorder.

IF 3 2区医学 Q2 CLINICAL NEUROLOGY

Nature and Science of Sleep Pub Date : 2024-06-21 eCollection Date: 2024-01-01 DOI:10.2147/NSS.S464055

Weiyu Cai, Le Chen, Yanyuan Dai, Baixin Chen, Dandan Zheng, Yun Li

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Abstract

Purpose: Major depressive disorder (MDD) is associated with cognitive impairment through unclear mechanisms. We examined the relationship between sleep electroencephalogram (EEG) power and attention level in MDD.

Patients and methods: Forty-seven untreated patients with MDD and forty-seven age- and sex-matched controls were included. We examined relative EEG power during non-rapid eye movement (NREM) sleep and rapid eye movement (REM) sleep by fast Fourier transform. The Attention Network Test (ANT) was performed to evaluate attention levels.

Results: Compared to controls, patients with MDD had lower theta power during NREM (P = 0.018) and REM (P = 0.002) sleep, while higher beta power (P = 0.050) during NREM sleep and delta power (P = 0.018) during REM sleep. Regarding attention level, patients with MDD had lower levels of accuracy (P = 0.021), longer mean reaction time (P < 0.001), poorer manifestations of the alerting effect (P = 0.038) and worse executive control (P = 0.048). Moreover, decreased theta power during NREM sleep was correlated with worsened accuracy (β = 0.329, P = 0.040), decreased theta power during REM sleep was correlated with worsened alerting effect (β = 0.355, P = 0.020), and increased delta power during REM sleep was correlated with longer mean reaction time (β = 0.325, P = 0.022) in patients with MDD. No association between ANT performance and other frequency bands was observed in patients with MDD.

Conclusion: Our findings suggest that patients with MDD manifest impaired selective attention function that is associated with decreased theta power during NREM/REM sleep and increased delta power during REM sleep.

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重度抑郁症患者睡眠时脑电图功率与注意力水平之间的关系

目的：重度抑郁障碍（MDD）与认知障碍相关的机制尚不清楚。我们研究了 MDD 患者的睡眠脑电图（EEG）功率与注意力水平之间的关系：纳入四十七名未经治疗的 MDD 患者和四十七名年龄和性别匹配的对照组患者。我们通过快速傅立叶变换检查了非快速眼动（NREM）睡眠和快速眼动（REM）睡眠时的相对脑电图功率。我们还进行了注意力网络测试（ANT），以评估注意力水平：与对照组相比，MDD 患者在 NREM（P = 0.018）和 REM（P = 0.002）睡眠期间的 Theta 功率较低，而在 NREM 睡眠期间的 beta 功率（P = 0.050）和 REM 睡眠期间的 delta 功率（P = 0.018）较高。在注意力水平方面，多发性硬化症患者的准确性较低（P = 0.021），平均反应时间较长（P < 0.001），警觉效应表现较差（P = 0.038），执行控制能力较差（P = 0.048）。此外，在 MDD 患者中，NREM 睡眠期间的 Theta 功率下降与准确性恶化相关（β = 0.329，P = 0.040），REM 睡眠期间的 Theta 功率下降与警觉效应恶化相关（β = 0.355，P = 0.020），REM 睡眠期间的 delta 功率增加与平均反应时间延长相关（β = 0.325，P = 0.022）。在 MDD 患者中未观察到 ANT 性能与其他频段之间的关联：我们的研究结果表明，多发性硬化症患者的选择性注意功能受损，这与NREM/REM睡眠期间θ功率下降和REM睡眠期间δ功率增加有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature and Science of Sleep Neuroscience-Behavioral Neuroscience

CiteScore

5.70

自引率

5.90%

发文量

245

审稿时长

16 weeks

期刊介绍： Nature and Science of Sleep is an international, peer-reviewed, open access journal covering all aspects of sleep science and sleep medicine, including the neurophysiology and functions of sleep, the genetics of sleep, sleep and society, biological rhythms, dreaming, sleep disorders and therapy, and strategies to optimize healthy sleep. Specific topics covered in the journal include: The functions of sleep in humans and other animals Physiological and neurophysiological changes with sleep The genetics of sleep and sleep differences The neurotransmitters, receptors and pathways involved in controlling both sleep and wakefulness Behavioral and pharmacological interventions aimed at improving sleep, and improving wakefulness Sleep changes with development and with age Sleep and reproduction (e.g., changes across the menstrual cycle, with pregnancy and menopause) The science and nature of dreams Sleep disorders Impact of sleep and sleep disorders on health, daytime function and quality of life Sleep problems secondary to clinical disorders Interaction of society with sleep (e.g., consequences of shift work, occupational health, public health) The microbiome and sleep Chronotherapy Impact of circadian rhythms on sleep, physiology, cognition and health Mechanisms controlling circadian rhythms, centrally and peripherally Impact of circadian rhythm disruptions (including night shift work, jet lag and social jet lag) on sleep, physiology, cognition and health Behavioral and pharmacological interventions aimed at reducing adverse effects of circadian-related sleep disruption Assessment of technologies and biomarkers for measuring sleep and/or circadian rhythms Epigenetic markers of sleep or circadian disruption.