Cannabidiol decreases histological intestinal injury in a neonatal experimental model of necrotizing enterocolitis.

IF 2.7 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Laboratory Animal Research Pub Date : 2024-06-27 DOI:10.1186/s42826-024-00211-9

Nerea Huertos Soto, Juan Manuel Gómez Cervantes, María Jesús Fernández Aceñero, María Del Carmen Soto Beauregard

{"title":"Cannabidiol decreases histological intestinal injury in a neonatal experimental model of necrotizing enterocolitis.","authors":"Nerea Huertos Soto, Juan Manuel Gómez Cervantes, María Jesús Fernández Aceñero, María Del Carmen Soto Beauregard","doi":"10.1186/s42826-024-00211-9","DOIUrl":null,"url":null,"abstract":"Background: Necrotizing enterocolitis (NEC) is a severe inflammatory bowel disease in neonates. Our group has developed an experimental model of NEC, with an effectiveness of 73%. Cannabidiol (CBD) is an innovative treatment for neonatal cerebral hypoxic-ischemic pathologies due to its neuroprotective effect, as a potent anti-inflammatory and reducing oxidative stress substance. Our aim was to evaluate the effect of CBD on intestinal lesions in an experimental model of NEC.Results: Mortality and intestinal histological damage was significantly lower in the CBD group compared to the rest (p<0.05), establishing CBD as a protective factor against the development of NEC (OR=0.0255; 95% CI=0.0015-0.4460). At IHQ level (TUNEL technique), a lower cell death rate was also observed in the CBD group compared to the VEH group (p<0.05).Conclusions: In our experimental model, intraperitoneal CBD acts as a protective factor against NEC, resulting in less histological damage and a lower rate of intestinal cell death.","PeriodicalId":17993,"journal":{"name":"Laboratory Animal Research","volume":"40 1","pages":"26"},"PeriodicalIF":2.7000,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11209976/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Laboratory Animal Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1186/s42826-024-00211-9","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Necrotizing enterocolitis (NEC) is a severe inflammatory bowel disease in neonates. Our group has developed an experimental model of NEC, with an effectiveness of 73%. Cannabidiol (CBD) is an innovative treatment for neonatal cerebral hypoxic-ischemic pathologies due to its neuroprotective effect, as a potent anti-inflammatory and reducing oxidative stress substance. Our aim was to evaluate the effect of CBD on intestinal lesions in an experimental model of NEC.

Results: Mortality and intestinal histological damage was significantly lower in the CBD group compared to the rest (p<0.05), establishing CBD as a protective factor against the development of NEC (OR=0.0255; 95% CI=0.0015-0.4460). At IHQ level (TUNEL technique), a lower cell death rate was also observed in the CBD group compared to the VEH group (p<0.05).

Conclusions: In our experimental model, intraperitoneal CBD acts as a protective factor against NEC, resulting in less histological damage and a lower rate of intestinal cell death.

查看原文本刊更多论文

在新生儿坏死性小肠结肠炎实验模型中，大麻二酚可减少组织学上的肠道损伤。

背景：坏死性小肠结肠炎（NEC坏死性小肠结肠炎（NEC）是新生儿的一种严重炎症性肠病。我们的研究小组开发了一种 NEC 实验模型，有效率达 73%。大麻二酚（CBD）作为一种强效抗炎和减少氧化应激的物质，具有神经保护作用，是治疗新生儿脑缺氧缺血性病变的一种创新疗法。我们的目的是评估 CBD 在 NEC 实验模型中对肠道病变的影响：结果：与其他组相比，CBD 组的死亡率和肠道组织学损伤明显降低（p 结论：在我们的实验模型中，小鼠腹腔注射 CBD 对肠道组织学损伤的影响较小：在我们的实验模型中，腹腔注射 CBD 对 NEC 有保护作用，可减少组织学损伤，降低肠细胞死亡率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊