Flow interruption compared to forced oscillatory maneuvers and esophageal balloon/pneumotachography for measurement of respiratory resistance in the horse.

IF 3.3 3区 医学 Q1 PHYSIOLOGY
Journal of applied physiology Pub Date : 2024-09-01 Epub Date: 2024-06-27 DOI:10.1152/japplphysiol.00213.2024
Melissa R Mazan, Christopher Simotas, Thomas Coons, Brian Barrow, Daniela Bedenice, Jill Minuto, Kristen Wendell, Edward F Deveney
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引用次数: 0

Abstract

Pulmonary function testing is critical to the diagnosis of equine asthma (EA), an important cause of respiratory disease in the horse, but its clinical use has remained elusive, unfortunately, due to the complexity of reference methods, esophageal balloon/pneumotachography (EBP), and forced oscillatory mechanics (FOM), so we sought a noninvasive, portable method for use in horses through rapid interruption of airflow for equilibration of alveolar pressure with proximal airway pressure, termed flow interruption (FI). Resistance (RINT) was computed as the relationship between the change in pressure at the nose before and immediately after interruption and flow immediately before interruption. A pilot study in five healthy university-owned animals using EBP and FI showed good correspondence between the two methods: RINT (0.33 ± 0.05 cmH2O/L/s) and RL (0.31 ± 0.06 cmH2O/L/s). In two separate populations of client-owned horses, with random assignment of methods to FI versus EBP (n = 8), RINT showed good correlation with RL in horses (rs = 0.995, P = 0.0002) and accords with RL, with no significant difference between RINT and RL. Using FOM (n = 12), RINT (0.67 ± 0.31 cmH2O/L/s) has good correlation with RRS measured with FOM (r = 0.834, P = 0.0001), but is consistently smaller than RRS (0.74 ± 0.33 cmH2O/L/s). Histamine bronchoprovocation (HBP) was performed in a subset of these horses: FI classified one horse in six as less reactive than did EBP, and FI classified one horse in seven as less reactive than did FOM.NEW & NOTEWORTHY We developed and document for the first time the use of flow interruption for the rapid and noninvasive measurement of resistance in equine patients and demonstrated short- and long-term stability and accuracy in comparison with the reference methods.

在测量马的呼吸阻力时,气流中断与强制振荡法和食道气囊气动描记术的比较。
肺功能测试是诊断马哮喘(EA)的关键,EA 是导致马呼吸道疾病的重要原因,但遗憾的是,由于参考方法、食道球囊/气道造影术 (EBP) 和强迫振荡力学 (FOM) 的复杂性,其临床应用一直难以实现,因此我们寻求一种无创、便携的方法,通过快速中断气流来平衡肺泡压力和近端气道压力,即气流中断 (FI),以用于马匹。阻力(RINT)是根据气流中断前后鼻腔压力变化与气流中断前气流之间的关系计算得出的。使用 EBP 和 FI 对 5 只健康的大学动物进行的试点研究表明,这两种方法之间存在良好的对应关系:RINT(0.33 +/- 0.05 cm H2O/l/s)和 RL(0.31 +/- 0.06 cm H2O/l/s)。在客户拥有的两匹马中,随机分配 FI 与 EBP 方法(n = 8),RINT 与 RL 在马匹中显示出良好的相关性(rs =.995,p = .0002),并且与 RL 一致,RINT 与 RL 之间没有显著差异。使用 FOM(n = 12),RINT(0.67 +/- 0.31 cmH2O/l/s)与使用 FOM 测量的 RRS 具有良好的相关性(r =.834,p = .0001),但始终小于 RRS(0.74 +/- 0.33 cmH2O/l/s)。对这些马中的一部分进行了组胺支气管舒张试验(HBP):与 EBP 相比,FI 将 6 匹马中的 1 匹归类为反应性较低的马,与 FOM 相比,FI 将 7 匹马中的 1 匹归类为反应性较低的马。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
6.00
自引率
9.10%
发文量
296
审稿时长
2-4 weeks
期刊介绍: The Journal of Applied Physiology publishes the highest quality original research and reviews that examine novel adaptive and integrative physiological mechanisms in humans and animals that advance the field. The journal encourages the submission of manuscripts that examine the acute and adaptive responses of various organs, tissues, cells and/or molecular pathways to environmental, physiological and/or pathophysiological stressors. As an applied physiology journal, topics of interest are not limited to a particular organ system. The journal, therefore, considers a wide array of integrative and translational research topics examining the mechanisms involved in disease processes and mitigation strategies, as well as the promotion of health and well-being throughout the lifespan. Priority is given to manuscripts that provide mechanistic insight deemed to exert an impact on the field.
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