{"title":"Design and Probing of Prism-Based SPR Nano-Biosensor for Human Sperm Detection.","authors":"Yesudasu Vasimalla, Baljinder Kaur, Suman Maloji, Santosh Kumar","doi":"10.1109/TNB.2024.3419571","DOIUrl":null,"url":null,"abstract":"<p><p>Human sperm functioning is crucial for maintaining natural reproduction, but its sterility is enhanced by variations in environmental conditions. Because of these agitating properties, powerful computer-aided devices are required, but their precision is inadequate, particularly when it comes to samples with low sperm concentrations. Therefore, for the first time, this article introduces the sulfide material-based structure for the detection of human sperm samples using the prism-based surface plasmon resonance sensor (SPR) Nano-biosensor. The proposed structure is designed on the basis of a prism-based Kretschmann configuration and includes silver, silicon, a sulfide layer, black phosphorus, and a sensing medium. This work takes advantage of the excitement of surface plasmons and evanescent waves in the metal dielectric region. For the detection process, seven sperm samples are taken, with their concentration, mobility, and refractive index measured by the refractometer. The proposed structure provides a maximum sensitivity of 409.17°/RIU, QF of 97.45RIU<sup>-1</sup> and a DA of 1.37. The results provide a substantial improvement in comparison to the reported work in the literature.</p>","PeriodicalId":13264,"journal":{"name":"IEEE Transactions on NanoBioscience","volume":null,"pages":null},"PeriodicalIF":3.7000,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"IEEE Transactions on NanoBioscience","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1109/TNB.2024.3419571","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMICAL RESEARCH METHODS","Score":null,"Total":0}
引用次数: 0
Abstract
Human sperm functioning is crucial for maintaining natural reproduction, but its sterility is enhanced by variations in environmental conditions. Because of these agitating properties, powerful computer-aided devices are required, but their precision is inadequate, particularly when it comes to samples with low sperm concentrations. Therefore, for the first time, this article introduces the sulfide material-based structure for the detection of human sperm samples using the prism-based surface plasmon resonance sensor (SPR) Nano-biosensor. The proposed structure is designed on the basis of a prism-based Kretschmann configuration and includes silver, silicon, a sulfide layer, black phosphorus, and a sensing medium. This work takes advantage of the excitement of surface plasmons and evanescent waves in the metal dielectric region. For the detection process, seven sperm samples are taken, with their concentration, mobility, and refractive index measured by the refractometer. The proposed structure provides a maximum sensitivity of 409.17°/RIU, QF of 97.45RIU-1 and a DA of 1.37. The results provide a substantial improvement in comparison to the reported work in the literature.
期刊介绍:
The IEEE Transactions on NanoBioscience reports on original, innovative and interdisciplinary work on all aspects of molecular systems, cellular systems, and tissues (including molecular electronics). Topics covered in the journal focus on a broad spectrum of aspects, both on foundations and on applications. Specifically, methods and techniques, experimental aspects, design and implementation, instrumentation and laboratory equipment, clinical aspects, hardware and software data acquisition and analysis and computer based modelling are covered (based on traditional or high performance computing - parallel computers or computer networks).