The Impact of Lifestyle on Cardiovascular Risk in Patients with Gout: a Population-based Cohort Study.

IF 5.4 3区材料科学 Q2 CHEMISTRY, PHYSICAL

ACS Applied Energy Materials Pub Date : 2024-06-26 DOI:10.1093/ehjqcco/qcae048

Seung Min Jung, Sang-Hyuk Jung, Su-Nam Lee, Jin A Choi, Dokyoon Kim, Hong-Hee Won, Ki-Jo Kim, Jae-Seung Yun

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引用次数: 0

Abstract

Aims: Gout is associated with a significant burden of cardiovascular disease. The aim of this study was to evaluate the impact of a favorable lifestyle on incident cardiovascular events in patients with gout.

Methods: We identified 9 110 patients with gout from the UK Biobank cohort based on self-report and/or hospital diagnostic codes. Lifestyle behaviors, including smoking status, physical activity, obesity, and diet, were categorized into three patterns: favorable (3-4 healthy factors), intermediate (2 healthy factors), and unfavorable (0-1 healthy factor). The cardiovascular risk of participants with and without gout was estimated based on their serum uric acid levels and lifestyle patterns.

Results: Among 9 110 patients with gout and 457 596 participants without gout, the median follow-up duration was 8.9 years. The incidence rate of cardiovascular disease was significantly higher in the gout population than in the non-gout population (11.38 vs 5.49 per 1000 person-years). The gout population consistently exhibited a high cardiovascular risk, irrespective of uric acid levels, whereas a positive correlation was observed between uric acid levels and cardiovascular risk in the non-gout population. Adopting a favorable lifestyle pattern was associated with a lower risk of cardiovascular disease in both gout and non-gout populations. Across all categories of uric acid, a favorable lifestyle was found to reduce cardiovascular risk in patients with gout.

Conclusion: Patients with gout remain at high risk of developing cardiovascular disease despite having normal uric acid levels. Lifestyle modifications may represent an effective and cost-efficient therapeutic approach for preventing cardiovascular events in this population.

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生活方式对痛风患者心血管风险的影响：一项基于人群的队列研究。

目的：痛风与严重的心血管疾病相关。本研究旨在评估良好的生活方式对痛风患者心血管事件的影响：根据自我报告和/或医院诊断代码，我们从英国生物库队列中确定了 9 110 名痛风患者。包括吸烟状况、体育锻炼、肥胖和饮食在内的生活方式行为被分为三种模式：有利模式（3-4 个健康因素）、中间模式（2 个健康因素）和不利模式（0-1 个健康因素）。根据参与者的血清尿酸水平和生活方式，估算出痛风患者和非痛风患者的心血管风险：在 9 110 名痛风患者和 457 596 名非痛风患者中，中位随访时间为 8.9 年。痛风人群的心血管疾病发病率明显高于非痛风人群（11.38 比 5.49/1000人-年）。无论尿酸水平如何，痛风人群的心血管风险都很高，而在非痛风人群中，尿酸水平与心血管风险之间呈正相关。在痛风和非痛风人群中，采用良好的生活方式与降低心血管疾病风险相关。在所有尿酸类别中，良好的生活方式都能降低痛风患者的心血管风险：结论：痛风患者尽管尿酸水平正常，但罹患心血管疾病的风险仍然很高。改变生活方式可能是预防痛风患者心血管疾病的有效且经济的治疗方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Energy Materials Materials Science-Materials Chemistry

CiteScore

10.30

自引率

6.20%

发文量

1368

期刊介绍： ACS Applied Energy Materials is an interdisciplinary journal publishing original research covering all aspects of materials, engineering, chemistry, physics and biology relevant to energy conversion and storage. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important energy applications.