Associations between urine glyphosate levels and metabolic health risks: insights from a large cross-sectional population-based study.

IF 5.3 2区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES
Sarah Otaru, Laura E Jones, David O Carpenter
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引用次数: 0

Abstract

Background: The prevalence of metabolic syndrome (MetS) in American adults increased from 37.6% in the 2011-12 period to 41.8% in 2017-2018. Environmental exposure, particularly to common compounds such as glyphosate, has drawn increasing attention as a potential risk factor.

Methods: We employed three cycles of data (2013-2018) from the National Health and Nutrition Examination Survey (NHANES) in a cross-sectional study to examine potential associations between urine glyphosate measurements and MetS incidence. We first created a MetS score using exploratory factor analysis (EFA) of the International Diabetes Federation (IDF) criteria for MetS, with data drawn from the 2013-2018 NHANES cycles, and validated this score independently on an additional associated metric, the albumin-to-creatinine (ACR) ratio. The score was validated via a machine learning approach in predicting the ACR score via binary classification and then used in multivariable regression to test the association between quartile-categorized glyphosate exposure and the MetS score.

Results: In adjusted multivariable regressions, regressions between quartile-categorized glyphosate exposure and MetS score showed a significant inverted U-shaped or saturating dose‒response profile, often with the largest effect for exposures in quartile 3. Exploration of potential effect modification by sex, race, and age category revealed significant differences by race and age, with older people (aged > 65 years) and non-Hispanic African American participants showing larger effect sizes for all exposure quartiles.

Conclusions: We found that urinary glyphosate concentration is significantly associated with a statistical score designed to predict MetS status and that dose-response coefficient is nonlinear, with advanced age and non-Hispanic African American, Mexican American and other Hispanic participants exhibiting greater effect sizes.

尿液中草甘膦含量与代谢健康风险之间的关系:一项大型横断面人群研究的启示。
背景:美国成年人的代谢综合征(MetS)患病率从 2011-12 年的 37.6% 上升到 2017-2018 年的 41.8%。环境暴露,尤其是草甘膦等常见化合物,作为潜在风险因素引起了越来越多的关注:我们在一项横断面研究中采用了美国国家健康与营养调查(NHANES)的三个周期(2013-2018 年)的数据,以研究尿液草甘膦测量值与 MetS 发病率之间的潜在关联。我们首先利用国际糖尿病联合会(IDF)的 MetS 标准进行探索性因子分析 (EFA),利用 2013-2018 年 NHANES 周期的数据创建了 MetS 评分,并根据白蛋白与肌酐 (ACR) 比值这一额外的相关指标对该评分进行了独立验证。通过二元分类预测 ACR 评分的机器学习方法对该评分进行了验证,然后将其用于多变量回归,以检验四分位草甘膦暴露与 MetS 评分之间的关联:结果:在调整后的多变量回归中,四分位草甘膦暴露量与 MetS 评分之间的回归结果显示出显著的倒 U 型或饱和剂量-反应曲线,四分位 3 的暴露量通常影响最大。通过性别、种族和年龄类别对潜在效应修正的探索发现,不同种族和年龄之间存在显著差异,老年人(年龄大于 65 岁)和非西班牙裔非洲裔美国人参与者在所有四分位数暴露中均表现出较大的效应大小:我们发现,尿液中草甘膦浓度与预测 MetS 状态的统计评分有显著相关性,而且剂量-反应系数是非线性的,高龄、非西班牙裔非洲裔美国人、墨西哥裔美国人和其他西班牙裔参与者表现出更大的效应大小。
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来源期刊
Environmental Health
Environmental Health 环境科学-公共卫生、环境卫生与职业卫生
CiteScore
10.10
自引率
1.70%
发文量
115
审稿时长
3.0 months
期刊介绍: Environmental Health publishes manuscripts on all aspects of environmental and occupational medicine and related studies in toxicology and epidemiology. Environmental Health is aimed at scientists and practitioners in all areas of environmental science where human health and well-being are involved, either directly or indirectly. Environmental Health is a public health journal serving the public health community and scientists working on matters of public health interest and importance pertaining to the environment.
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