Feasibility of an Online Acute Stressor in Preschool Children of Mothers with Depression

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-06-25 DOI:10.1002/dev.22520

Allyson Paton, Shaelyn Stienwandt, Lara Penner-Goeke, Ryan J. Giuliano, Leslie E. Roos

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Abstract

Maternal depression is a risk factor for future mental health problems in offspring, with stress-system function as a candidate vulnerability factor. Here we present initial validation of an online matching-task (MT) paradigm in young children exposed to maternal depression (N = 40), a first in stressor-paradigm research for this age group. Investigations of stress-system reactivity that can be conducted online are an innovative assessment approach, accelerated by the COVID-19 pandemic. Results indicate high feasibility, with a >75% data collection success rate across measures, similar-to or better-than in-person success rates in young children. Overall, the online MT elicited significant heart rate but not cortisol reactivity. Individual differences in child mental health symptoms were a moderator of reactivity to the stressor such that children with lower, but not higher, behavioral problems exhibited the typical pattern of cortisol reactivity to the online MT. Results are aligned with allostatic load models, which suggest downregulation of stress-system reactivity as a result of experiencing adversity and mental health vulnerability. Consistent with in-person research, this suggests that an early phenotype for the emergence of behavior problems may be linked to altered stress-system reactivity. Results hold potential clinical implications for intervention development and the future of online stress-system research.

Trial Registration: Clinical Trial Registration: NCT04639557; (Building Regulation in Dual Generations—Telehealth Model [BRIDGE]).

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在母亲患有抑郁症的学龄前儿童中开展在线急性压力测试的可行性。

母亲抑郁是导致后代未来出现心理健康问题的一个风险因素，而压力系统功能则是一个候选的脆弱因素。在此，我们介绍了一种在线匹配任务（MT）范式的初步验证结果，该范式适用于受到母亲抑郁影响的幼儿（40 人），这在该年龄组的压力源范式研究中尚属首次。可在线进行的压力系统反应性调查是一种创新的评估方法，COVID-19 大流行加速了这种方法的发展。研究结果表明，该方法具有很高的可行性，各项措施的数据收集成功率大于 75%，类似于或优于幼儿的现场成功率。总体而言，在线 MT 能引起明显的心率反应，但皮质醇反应不明显。儿童心理健康症状的个体差异是压力反应的调节因素，因此行为问题较少而非较多的儿童对在线 MT 表现出典型的皮质醇反应模式。研究结果与异质负荷模型相一致，后者表明压力系统反应性的下调是经历逆境和心理健康脆弱性的结果。这表明，行为问题出现的早期表型可能与压力系统反应性的改变有关。研究结果对干预措施的开发和在线压力系统研究的未来具有潜在的临床意义。试验注册：临床试验注册：NCT04639557；（Building Regulation in Dual Generations-Telehealth Model [BRIDGE]）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.